Zinc finger and scan domain containing 4 explained
Zinc finger and SCAN domain containing 4 is a protein that in humans is encoded by the ZSCAN4 gene.[1]
Function
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture.[2]
Further reading
- Lee K, Gollahon LS . Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status . Cancer Biol. Ther. . 15 . 8 . 1094–105 . 2014 . 24840609 . 4119077 . 10.4161/cbt.29220 .
- Lee K, Gollahon LS . ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity . Biochem. Biophys. Res. Commun. . 466 . 4 . 644–9 . 2015 . 26403970 . 10.1016/j.bbrc.2015.09.107 .
- Ishiguro KI, Nakatake Y, Chikazawa-Nohtomi N, Kimura H, Akiyama T, Oda M, Ko SB, Ko MS . Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos . In Vitro Cell. Dev. Biol. Anim. . 53 . 2 . 179–190 . 2017 . 27699651 . 5311086 . 10.1007/s11626-016-0097-y .
Notes and References
- Web site: Entrez Gene: Zinc finger and SCAN domain containing 4. 2017-06-05.
- Ko. Minoru S. H.. Wersto. Robert P.. Indig. Fred E.. Yang. Hsih-Te. Hoang. Hien G.. Carole A. Stagg. Lee. Sung-Lim. Thomas. Marshall. Nishiyama. Akira. April 2010. Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature. 464. 7290. 858–863. 10.1038/nature08882. 20336070. 1476-4687. 2851843. 2010Natur.464..858Z.