ZNRD1 explained

DNA-directed RNA polymerase I subunit RPA12 is an enzyme that in humans is encoded by the ZNRD1 gene.^{[1] [2] [3]}

Function

This gene encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Coriton O, Lepourcelet M, Hampe A, Galibert F, Mosser J . Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes . Mammalian Genome . 11 . 12 . 1127–31 . Dec 2000 . 11130983 . 10.1007/s003350010213 . 22881226 .
• Shi Y, Zhang Y, Zhao Y, Hong L, Liu N, Jin X, Pan Y, Fan D . Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein . Cancer Biology & Therapy . 3 . 4 . 377–81 . Apr 2004 . 14726695 . 10.4161/cbt.3.4.724 . free .
• Hong L, Zhang Y, Liu N, Liu C, Zhi M, Pan Y, Lan M, Sun L, Fan D . Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene . Biochemical and Biophysical Research Communications . 321 . 3 . 611–6 . Aug 2004 . 15358150 . 10.1016/j.bbrc.2004.07.007 .
• Hong L, Han Y, Shi R, Shao X, Sun L, Zhang Y, Huang D, Chen Z, Zhang G, Liang J, Hu S, Fan D . ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase . Cancer Biology & Therapy . 4 . 1 . 60–4 . Jan 2005 . 15662122 . 10.4161/cbt.4.1.1375 . free .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Hong L, Zhao Y, Han Y, Guo W, Jin H, Qiao T, Che Z, Fan D . Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells . Carcinogenesis . 28 . 8 . 1622–8 . Aug 2007 . 17389617 . 10.1093/carcin/bgm064 . free .
• Hong L, Wang J, Zhao Y, Han Z, Zhou X, Guo W, Zhang X, Jin H, Wu K, Ding J, Fan D . DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1 . Cancer Investigation . 25 . 8 . 699–705 . Dec 2007 . 18058465 . 10.1080/07357900701566304 . 34324190 .

Notes and References

1. Lepourcelet M, Andrieux N, Giffon T, Pichon L, Hampe A, Galibert F, Mosser J . Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence . Genomics . 37 . 3 . 316–26 . Nov 1996 . 8938444 . 10.1006/geno.1996.0566 .
2. Fan W, Wang Z, Kyzysztof F, Prange C, Lennon G . A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region . Genomics . 63 . 1 . 139–41 . Jan 2000 . 10662553 . 10.1006/geno.1999.6040 .
3. Web site: Entrez Gene: ZNRD1 zinc ribbon domain containing 1.