CNBP explained

Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene.^{[1] [2] [3]}

Function

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM]^[3]

Further reading

• Rajavashisth TB, Taylor AK, Andalibi A, Svenson KL, Lusis AJ . Identification of a zinc finger protein that binds to the sterol regulatory element . Science . 245 . 4918 . 640–3 . Aug 1989 . 2562787 . 10.1126/science.2562787 . 1989Sci...245..640R .
• Flink IL, Morkin E . Organization of the gene encoding cellular nucleic acid-binding protein . Gene . 163 . 2 . 279–82 . Oct 1995 . 7590281 . 10.1016/0378-1119(95)00421-2 .
• Warden CH, Krisans SK, Purcell-Huynh D, Leete LM, Daluiski A, Diep A, Taylor BA, Lusis AJ . Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing . Genomics . 24 . 1 . 14–9 . Nov 1994 . 7896269 . 10.1006/geno.1994.1576 .
• Ricker K, Grimm T, Koch MC, Schneider C, Kress W, Reimers CD, Schulte-Mattler W, Mueller-Myhsok B, Toyka KV, Mueller CR . Linkage of proximal myotonic myopathy to chromosome 3q . Neurology . 52 . 1 . 170–1 . Jan 1999 . 9921867 . 10.1212/wnl.52.1.170 . 693401 .
• McGrath CF, Buckman JS, Gagliardi TD, Bosche WJ, Coren LV, Gorelick RJ . Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein . Journal of Virology . 77 . 15 . 8524–31 . Aug 2003 . 12857921 . 165261 . 10.1128/JVI.77.15.8524-8531.2003 .
• Vallo L, Bonifazi E, Borgiani P, Novelli G, Botta A . Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population . Molecular and Cellular Probes . 19 . 1 . 71–4 . Feb 2005 . 15652222 . 10.1016/j.mcp.2004.09.003 .
• Botta A, Caldarola S, Vallo L, Bonifazi E, Fruci D, Gullotta F, Massa R, Novelli G, Loreni F . Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2) . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease . 1762 . 3 . 329–34 . Mar 2006 . 16376058 . 10.1016/j.bbadis.2005.11.004 . free .
• Margolis JM, Schoser BG, Moseley ML, Day JW, Ranum LP . DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression . Human Molecular Genetics . 15 . 11 . 1808–15 . Jun 2006 . 16624843 . 10.1093/hmg/ddl103 . free .
• Toth C, Dunham C, Suchowersky O, Parboosingh J, Brownell K . Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2 . Muscle & Nerve . 35 . 2 . 259–64 . Feb 2007 . 17068784 . 10.1002/mus.20685 . 24178593 .
• Gerbasi VR, Link AJ . The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation . Molecular & Cellular Proteomics . 6 . 6 . 1049–58 . Jun 2007 . 17327219 . 10.1074/mcp.M600384-MCP200 . 2018887 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

External links

• GeneReviews/NCBI/NIH/UW entry on Myotonic Dystrophy Type 2

Notes and References

1. Lusis AJ, Rajavashisth TB, Klisak I, Heinzmann C, Mohandas T, Sparkes RS . Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24 . Genomics . 8 . 2 . 411–4 . Oct 1990 . 2249857 . 10.1016/0888-7543(90)90303-C .
2. Liquori CL, Ricker K, Moseley ML, Jacobsen JF, Kress W, Naylor SL, Day JW, Ranum LP . Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9 . Science . 293 . 5531 . 864–7 . Aug 2001 . 11486088 . 10.1126/science.1062125 . 30903810 .
3. Web site: Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein.