ZNF865 explained

ZNF865[1] (also referred to as BLST [2-4][2]) is a C2H2 member of the zinc finger family of proteins. Structurally, ZNF865 consists of 20 different zinc finger domains, 6 disordered regions, 2 transactivation domains, and 2 TGEKP domains.[3] Diseases associated with ZNF865 expression include Parkinson’s disease, esophageal cancer, and musculoskeletal diseases. Lack of expression of ZNF865 has been associated with increased incidence of Parkinson’s disease,[4] worse outcome measures in esophageal cancer, and increased incidence of musculoskeletal diseases.

Broadly, ZNF865 is expressed across all human cell and tissue types.[3] [5] Bioinformatics analysis predicts ZNF865 to be localized to the nucleus, and function in metal ion binding, DNA-binding transcription factor activity, interact with RNA polymerase II, and regulate transcription by RNA polymerase II.[5] Experimental data displays ZNF865 is a regulator of cellular senescence, cell cycle progression, DNA replication, DNA repair, and protein processing.[6] Lack of expression of ZNF865 induces cellular senescence, indicating that ZNF865 expression is necessary for healthy cell function. While increased expression of ZNF865 results in a shift in the cell cycle, increased rates of DNA replication and proliferation rates. Overall, ZNF865 has been confirmed as a regulator of cellular senescence, cell cycle progression, and DNA replication.[7]

Notes and References

  1. Web site: ZNF865 .
  2. Levis . Hunter . Lewis . Christian . Fainor . Matthew . Lawal . Ameerah . Stockham . Elise . Weston . Jacob . Farhang . Niloofar . Gullbrand . Sarah E. . Bowles . Robby D. . 2024-11-08 . Targeted CRISPR regulation of ZNF865 enhances stem cell cartilage deposition, tissue maturation rates, and mechanical properties in engineered intervertebral discs . Acta Biomaterialia . 10.1016/j.actbio.2024.11.007 . 1742-7061.
  3. Web site: UniProt . www.uniprot.org.
  4. Hong K, Yang Q, Yin H, Wei N, Wang W, Yu B . Comprehensive analysis of ZNF family genes in prognosis, immunity, and treatment of esophageal cancer . BMC Cancer . 23 . 1 . 301 . April 2023 . 37013470 . 10069130 . 10.1186/s12885-023-10779-5 . free .
  5. Web site: Subcellular - ZNF865 - The Human Protein Atlas . www.proteinatlas.org.
  6. Levis . Hunter . Lewis . Christian . Fainor . Matthew . Lawal . Ameerah . Stockham . Elise . Weston . Jacob . Farhang . Niloofar . Gullbrand . Sarah E. . Bowles . Robby D. . 2024-11-08 . Targeted CRISPR regulation of ZNF865 enhances stem cell cartilage deposition, tissue maturation rates, and mechanical properties in engineered intervertebral discs . Acta Biomaterialia . 10.1016/j.actbio.2024.11.007 . 1742-7061.
  7. Levis . Hunter . Lewis . Christian . Fainor . Matthew . Lawal . Ameerah . Stockham . Elise . Weston . Jacob . Farhang . Niloofar . Gullbrand . Sarah E. . Bowles . Robby D. . 2024-11-08 . Targeted CRISPR regulation of ZNF865 enhances stem cell cartilage deposition, tissue maturation rates, and mechanical properties in engineered intervertebral discs . Acta Biomaterialia . 10.1016/j.actbio.2024.11.007 . 1742-7061.

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