ZNF74 explained

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.^{[1] [2] [3]} Schizophrenia susceptibility has been associated with a mutation in this protein.^[4]

Interactions

ZNF74 has been shown to interact with POLR2A.^[5]

Further reading

• Aubry M, Demczuk S, Desmaze C, Aikem M, Aurias A, Julien JP, Rouleau GA . Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome . Hum. Mol. Genet. . 2 . 10 . 1583–7 . 1994 . 8268910 . 10.1093/hmg/2.10.1583 .
• Grondin B, Bazinet M, Aubry M . The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix . J. Biol. Chem. . 271 . 26 . 15458–67 . 1996 . 8663113 . 10.1074/jbc.271.26.15458 . free .
• Grondin B, Côté F, Bazinet M, Vincent M, Aubry M . Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit . J. Biol. Chem. . 272 . 44 . 27877–85 . 1997 . 9346935 . 10.1074/jbc.272.44.27877 . free .
• Ravassard P, Côté F, Grondin B, Bazinet M, Mallet J, Aubry M . ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia . Genomics . 62 . 1 . 82–5 . 2000 . 10585771 . 10.1006/geno.1999.5982 .
• Côté F, Boisvert FM, Grondin B, Bazinet M, Goodyer CG, Bazett-Jones DP, Aubry M . Alternative promoter usage and splicing of ZNF74 multifinger gene produce protein isoforms with a different repressor activity and nuclear partitioning . DNA Cell Biol. . 20 . 3 . 159–73 . 2001 . 11313019 . 10.1089/104454901300069004 .
• Takase K, Ohtsuki T, Migita O, Toru M, Inada T, Yamakawa-Kobayashi K, Arinami T . Association of ZNF74 gene genotypes with age-at-onset of schizophrenia . . 52 . 3 . 161–5 . 2001 . 11705709 . 10.1016/S0920-9964(00)00191-2 . 42865851 .
• Germain-Desprez D, Bazinet M, Bouvier M, Aubry M . Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells . J. Biol. Chem. . 278 . 25 . 22367–73 . 2003 . 12684500 . 10.1074/jbc.M302234200 . free .
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 545604 . 10.1186/gb-2004-5-10-r84 . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .

Notes and References

1. Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA . Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2) . Genomics . 13 . 3 . 641–8 . August 1992 . 1639391 . 10.1016/0888-7543(92)90135-F .
2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . December 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
3. Web site: Entrez Gene: ZNF74 zinc finger protein 74.
4. Takase. K.. T. Ohtsuki . O. Migita . M. Toru . T. Inada . K. Yamakawa-Kobayashi . T. Arinami . Association of ZNF74 gene genotypes with age-at-onset of schizophrenia. Schizophrenia Research. 1 December 2001. 52. 3. 161–165. 10.1016/s0920-9964(00)00191-2. 11705709. 42865851.
5. Grondin B, Côté F, Bazinet M, Vincent M, Aubry M . Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit . J. Biol. Chem. . 272 . 44 . 27877–85 . October 1997 . 9346935 . 10.1074/jbc.272.44.27877 . free .