ZNF644 explained

Zing finger protein 644 (ZNF644) also known as zinc finger motif enhancer-binding protein 2 (Zep-2) is a protein that in humans is encoded by the ZNF644 gene.^[1]

Clinical relevance

Mutations in the ZNF644 gene have been found in sporadic cases of high myopia.^[2]

Further reading

• Zabaneh D, Balding DJ . A genome-wide association study of the metabolic syndrome in Indian Asian men. . PLOS ONE . 5 . 8 . e11961 . 2010 . 20694148 . 10.1371/journal.pone.0011961 . 2915922. 2010PLoSO...511961Z . free .
• Mulligan P, Westbrook TF, Ottinger M, etal . CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. . Mol. Cell . 32 . 5 . 718–26 . 2008 . 19061646 . 10.1016/j.molcel.2008.10.025 . 6595072 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446. 2004PNAS..10112130B . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Zhang QH, Ye M, Wu XY, etal . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. . Genome Res. . 10 . 10 . 1546–60 . 2000 . 11042152 . 10.1101/gr.140200 . 310934.

Notes and References

1. Web site: Entrez Gene: zinc finger protein 644.
2. 10.1371/journal.pgen.1002084 . Exome Sequencing Identifies ZNF644 Mutations in High Myopia . PLOS Genetics . 2011 . 7 . 6 . e1002084 . Yi . Shi . 21695231 . 3111487 . free .