ZNF598 explained

Zinc finger protein 598 (ZNF598) is a protein that in humans is encoded by the ZNF598 gene.[1]

Function

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex.[2] The complex is thought to function as a translation repressor in embryonic development. ZNF598 and its yeast homologue Hel2 are ubiquitin ligases that ubiquitinate the 40S ribosomal subunit during ribosome-associated protein quality control.[3] [4] [5] [6]

Notes and References

  1. Web site: Entrez Gene: Zinc finger protein 598 .
  2. Morita . Masahiro . Ler . Lian Wee . Fabian . Marc R. . Siddiqui . Nadeem . Mullin . Michael . Henderson . Valerie C. . Alain . Tommy . Fonseca . Bruno D. . Karashchuk . Galina . Bennett . Christopher F. . Kabuta . Tomohiro . Higashi . Shinji . Larsson . Ola . Topisirovic . Ivan . Smith . Robert J. . September 2012 . A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development . Molecular and Cellular Biology . 32 . 17 . 3585–3593 . 10.1128/MCB.00455-12 . 1098-5549 . 3422012 . 22751931.
  3. Juszkiewicz S, Hegde RS . Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination . Molecular Cell . 65 . 4 . 743–750.e4 . February 2017 . 28065601 . 10.1016/j.molcel.2016.11.039 . 5316413 .
  4. Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ . ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation . Molecular Cell . 65 . 4 . 751–760.e4 . February 2017 . 28132843 . 10.1016/j.molcel.2016.12.026 . 5321136 .
  5. Sitron CS, Park JH, Brandman O . Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation . RNA . 23 . 5 . 798–810 . May 2017 . 28223409 . 10.1261/rna.060897.117 . 5393187.
  6. Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T . Ubiquitination of stalled ribosome triggers ribosome-associated quality control . Nature Communications . 8 . 1 . 159 . July 2017 . 28757607 . 10.1038/s41467-017-00188-1 . 5534433. 2017NatCo...8..159M .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ZNF598".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.