ZNF202 explained

Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.^{[1] [2]}

Clinical significance

Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.^[3]

References

Further reading

• Book: Zinc finger proteins: from atomic contact to cellular function . Molecular biology intelligence unit . Iuchi S, Kuldell N . Springer Japan Co., Ltd.. 2005 . 0-306-48229-0 . 161 .
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ . Antigens recognized by autologous antibody in patients with renal-cell carcinoma . International Journal of Cancer . 83 . 4 . 456–464 . November 1999 . 10508479 . 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . 21839750 .
• Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S . The SCAN domain mediates selective oligomerization . The Journal of Biological Chemistry . 275 . 22 . 17173–17179 . June 2000 . 10747874 . 10.1074/jbc.M000119200 . free .
• Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR . A broad role for the zinc finger protein ZNF202 in human lipid metabolism . The Journal of Biological Chemistry . 275 . 21 . 15685–15690 . May 2000 . 10748193 . 10.1074/jbc.M910152199 . free .
• Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G . The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux . The Journal of Biological Chemistry . 276 . 15 . 12427–12433 . April 2001 . 11279031 . 10.1074/jbc.M100218200 . free .
• Babb R, Bowen BR . SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain . The Biochemical Journal . 370 . Pt 2 . 719–727 . March 2003 . 12444922 . 1223195 . 10.1042/BJ20021378 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . October 2005 . 16189514 . 10.1038/nature04209 . 4427026 . Huda Zoghbi . 2005Natur.437.1173R .
• Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A . Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population . Journal of Lipid Research . 47 . 5 . 944–952 . May 2006 . 16467280 . 10.1194/jlr.M500521-JLR200 . free .

Notes and References

1. Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M . Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins . Genomics . 52 . 3 . 358–362 . September 1998 . 9790754 . 10.1006/geno.1998.5419 .
2. Web site: Entrez Gene: ZNF202 zinc finger protein 202.
3. Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A . Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study . Atherosclerosis . 188 . 1 . 43–50 . September 2006 . 16289551 . 10.1016/j.atherosclerosis.2005.10.014 .