ZNF160 explained

Zinc finger protein 160 is a protein that, in humans, is encoded by the ZNF160 gene.^{[1] [2] [3]}

The protein encoded by this gene is a Krüppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Two alternative transcripts encoding the same isoform have been described.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mark C, Looman C, Abrink M, Hellman L . Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19. . DNA Cell Biol. . 20 . 5 . 275–86 . 2001 . 11410164 . 10.1089/104454901750232472 .
• Hattori A, Okumura K, Nagase T, etal . Characterization of long cDNA clones from human adult spleen. . DNA Res. . 7 . 6 . 357–66 . 2001 . 11214971 . 10.1093/dnares/7.6.357 . free .
• Nagase T, Kikuno R, Nakayama M, etal . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 4 . 273–81 . 2001 . 10997877 . 10.1093/dnares/7.4.271. free .

Notes and References

1. Halford S, Mattei MG, Daw S, Scambler PJ . A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4 . Genomics . 25 . 1 . 322–3 . Jul 1995 . 7774943 . 10.1016/0888-7543(95)80149-G .
2. Abrink M, Aveskogh M, Hellman L . Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937 . DNA Cell Biol . 14 . 2 . 125–36 . Mar 1995 . 7865130 . 10.1089/dna.1995.14.125 .
3. Web site: Entrez Gene: ZNF160 zinc finger protein 160.