ZNF10 explained

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.^[3]

Interactions

ZNF10 has been shown to interact with TRIM28.^{[4] [5]}

Further reading

• Huebner K, Druck T, Croce CM, Thiesen HJ . Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering . American Journal of Human Genetics . 48 . 4 . 726–40 . Apr 1991 . 2014798 . 1682948 .
• Thiesen HJ . Multiple genes encoding zinc finger domains are expressed in human T cells . The New Biologist . 2 . 4 . 363–74 . Apr 1990 . 2288909 .
• Vissing H, Meyer WK, Aagaard L, Tommerup N, Thiesen HJ . Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins . FEBS Letters . 369 . 2–3 . 153–7 . Aug 1995 . 7649249 . 10.1016/0014-5793(95)00728-R . 8254920 . free .
• Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W . Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1 . Nucleic Acids Research . 24 . 24 . 4859–67 . Dec 1996 . 9016654 . 146346 . 10.1093/nar/24.24.4859 .
• Moosmann P, Georgiev O, Thiesen HJ, Hagmann M, Schaffner W . Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor . Biological Chemistry . 378 . 7 . 669–77 . Jul 1997 . 9278146 . 10.1515/bchm.1997.378.7.669 . free .
• Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ . Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain . The Journal of Biological Chemistry . 275 . 24 . 18000–10 . Jun 2000 . 10748030 . 10.1074/jbc.M001499200 . free .
• Lorenz P, Koczan D, Thiesen HJ . Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation . Biological Chemistry . 382 . 4 . 637–44 . Apr 2001 . 11405226 . 10.1515/BC.2001.075 . 13200652 .

Notes and References

1. Abrink M, Aveskogh M, Hellman L . Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937 . DNA and Cell Biology . 14 . 2 . 125–36 . Feb 1995 . 7865130 . 10.1089/dna.1995.14.125 .
2. Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seité P, Thiesen HJ, Berger R . Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19 . Human Genetics . 92 . 6 . 583–7 . Dec 1993 . 8262519 . 10.1007/BF00420943 . 19201834 .
3. Web site: Entrez Gene: ZNF10 zinc finger protein 10.
4. Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W . Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1 . Nucleic Acids Research . 24 . 24 . 4859–67 . Dec 1996 . 9016654 . 146346 . 10.1093/nar/24.24.4859 .
5. Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ . Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain . The Journal of Biological Chemistry . 275 . 24 . 18000–10 . Jun 2000 . 10748030 . 10.1074/jbc.M001499200 . free .