ZMYND8 explained

Protein kinase C-binding protein 1 is an enzyme that in humans is encoded by the ZMYND8 gene.^[1]

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Mahony D, Kalionis B, Antalis TM . Plasminogen activator inhibitor type-2 (PAI-2) gene transcription requires a novel NF-kappaB-like transcriptional regulatory motif . Eur. J. Biochem. . 263 . 3 . 765–72 . 1999 . 10469140 . 10.1046/j.1432-1327.1999.00552.x .
• Hirosawa M . Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain . DNA Res. . 6 . 5 . 329–36 . 2000 . 10574461 . 10.1093/dnares/6.5.329 . Nagase T . Ishikawa K . 3 . Kikuno . R . Nomura . N . Ohara . O . free .
• Fossey SC . Identification and characterization of PRKCBP1, a candidate RACK-like protein . Mamm. Genome . 11 . 10 . 919–25 . 2000 . 11003709 . 10.1007/s003350010174 . Kuroda S . Price JA . 3 . Pendleton . Joanne K. . Freedman . Barry I. . Bowden . Donald W. . 646555 .
• Eichmuller S . Serological detection of cutaneous T-cell lymphoma-associated antigens . Proc. Natl. Acad. Sci. U.S.A. . 98 . 2 . 629–34 . 2001 . 11149944 . 10.1073/pnas.021386498 . 14639 . Usener D . Dummer R . 3 . Stein . A . Thiel . D . Schadendorf . D . free .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . Matthews LH . Ashurst J . 3 . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Galey D . Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes . J. Neurovirol. . 9 . 3 . 358–71 . 2003 . 12775419 . 10.1080/13550280390201119 . Becker K . Haughey N . 3 . Kalehua . A. . Taub . D. . Woodward . J. . Mattson . MP . Nath . A. . 22016092 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Westendorf JJ, Koka S . Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics . J. Cell. Biochem. . 92 . 1 . 29–41 . 2004 . 15095401 . 10.1002/jcb.20031 . 40202935 .
• Colland F . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . Jacq X . Trouplin V . 3 . Mougin . C . Groizeleau . C . Hamburger . A . Meil . A . Wojcik . J . Legrain . P .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Miles RR, Crockett DK, Lim MS, Elenitoba-Johnson KS . Analysis of BCL6-interacting proteins by tandem mass spectrometry . Mol. Cell. Proteomics . 4 . 12 . 1898–909 . 2006 . 16147992 . 10.1074/mcp.M500112-MCP200 . free .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . Hao T . Shaw C . 3 . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . 13709685 . free .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free .

Notes and References

1. Web site: Entrez Gene: ZMYND8 zinc finger, MYND-type containing 8.