ZKSCAN5 explained
Zinc finger protein with KRAB and SCAN domains 5 is a protein that in humans is encoded by the ZKSCAN5 gene.[1] [2] The protein contains a SCAN box and a KRAB A domain.
A similar protein in mice is differentially expressed in spermatogenesis. Two alternatively spliced transcript variants differing only in the five prime untranslated region (5' UTR) have been described. Additional variants have been found, but their full-length sequences have not been determined.[3]
Further reading
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
- Nagase T, Ishikawa K, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 1 . 63–70 . 1999 . 10231032 . 10.1093/dnares/6.1.63 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S .
- Hillier LW, Fulton RS, Fulton LA, etal . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . free .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Thompson EE, Kuttab-Boulos H, Yang L, etal . Sequence diversity and haplotype structure at the human CYP3A cluster. . Pharmacogenomics J. . 6 . 2 . 105–14 . 2006 . 16314882 . 10.1038/sj.tpj.6500347 . free .
- Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
Notes and References
- Dreyer SD, Zheng Q, Zabel B, Winterpacht A, Lee B . Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain . Genomics . 62 . 1 . 119–22 . Feb 2000 . 10585779 . 10.1006/geno.1999.5981 .
- Web site: Entrez Gene: ZKSCAN5 zinc finger with KRAB and SCAN domains 5.
- Web site: Entrez Gene: ZKSCAN5 zinc finger with KRAB and SCAN domains 5.
