Zinc transporter ZIP1 explained

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.^{[1] [2] [3]}

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.^[4]

See also

• Solute carrier family

Further reading

• Lai CH, Chou CY, Ch'ang LY, etal . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 10.1101/gr.10.5.703 . 310876 .
• Gaither LA, Eide DJ . The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. . J. Biol. Chem. . 276 . 25 . 22258–64 . 2001 . 11301334 . 10.1074/jbc.M101772200 . free .
• Milon B, Dhermy D, Pountney D, etal . Differential subcellular localization of hZip1 in adherent and non-adherent cells. . FEBS Lett. . 507 . 3 . 241–6 . 2001 . 11696349 . 10.1016/S0014-5793(01)02950-7 . 19962909 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Franklin RB, Ma J, Zou J, etal . Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. . J. Inorg. Biochem. . 96 . 2–3 . 435–42 . 2003 . 12888280 . 10.1016/S0162-0134(03)00249-6 . 4465841 .
• Dufner-Beattie J, Langmade SJ, Wang F, etal . Structure, function, and regulation of a subfamily of mouse zinc transporter genes . J. Biol. Chem. . 278 . 50 . 50142–50 . 2004 . 14525987 . 10.1074/jbc.M304163200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Franklin RB, Feng P, Milon B, etal . hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer . Mol. Cancer . 4 . 32 . 2006 . 16153295 . 10.1186/1476-4598-4-32 . 1243239 . free .
• Tang Z, Sahu SN, Khadeer MA, etal . Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells . Bone . 38 . 2 . 181–98 . 2006 . 16203195 . 10.1016/j.bone.2005.08.010 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Huang L, Kirschke CP . A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein . FEBS J. . 274 . 15 . 3986–97 . 2007 . 17635580 . 10.1111/j.1742-4658.2007.05933.x . 21792127 . free .

Notes and References

1. Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J . Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex . Genomics . 62 . 2 . 272–80 . Feb 2000 . 10610721 . 10.1006/geno.1999.5993 .
2. Gaither LA, Eide DJ . Functional expression of the human hZIP2 zinc transporter . J Biol Chem . 275 . 8 . 5560–4 . Mar 2000 . 10681536 . 10.1074/jbc.275.8.5560 . free .
3. Web site: Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1.
4. Costello LC, Franklin RB . The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots . Mol. Cancer . 5 . 17 . 2006 . 16700911 . 1481516 . 10.1186/1476-4598-5-17 . free .