ZHX3 explained

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.^{[1] [2]}

This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded Protein contains two C2H2-type zinc fingers and five Homeodomains and forms a Dimer with itself or with Zinc fingers and homeoboxes family member 1. In the Nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor.fx

Further reading

• Nakajima D . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . vanc. Okazaki N . Yamakawa H . 3 . Kikuno . R . Ohara . O . Nagase . T . free .
• Liu G . ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome . J. Biol. Chem. . 281 . 51 . 39681–92 . 2007 . 17056598 . 10.1074/jbc.M606664200 . vanc. Clement LC . Kanwar YS . 3 . Avila-Casado . C. . Chugh . S. S. . free .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . vanc. Hao T . Shaw C . 3 . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . 13709685 . free .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . vanc. Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Kawata H . The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3 . Gene . 323 . 133–40 . 2004 . 14659886 . 10.1016/j.gene.2003.09.013 . vanc. Yamada K . Shou Z . 3 . Mizutani . T . Miyamoto . K .
• Yamada K . Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3 . Biochem. J. . 373 . Pt 1 . 167–78 . 2003 . 12659632 . 10.1042/BJ20021866 . 1223464 . vanc. Kawata H . Shou Z . 3 . Hirano . Satoko . Mizutani . Tetsuya . Yazawa . Takashi . Sekiguchi . Toshio . Yoshino . Miki . Kajitani . Takashi .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Jia L . Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis . Genomics . 79 . 1 . 7–17 . 2002 . 11827452 . 10.1006/geno.2001.6683 . vanc. Young MF . Powell J . 3 . Yang . Liming . Ho . Nicola C. . Hotchkiss . Robert . Robey . Pamela Gehron . Francomano . Clair A. .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . vanc. Matthews LH . Ashurst J . 3 . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . free . 2001Natur.414..865D .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 4 . 5 . 307–13 . Feb 1998 . 9455477 . 10.1093/dnares/4.5.307 . free .
2. Web site: Entrez Gene: ZHX3 zinc fingers and homeoboxes 3.