ZHX2 explained

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.^{[1] [2] [3]}

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.

See also

• Chromosome 8 (human)
• NFYA
• Protein dimer

Further reading

• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Kawata H . The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3 . Gene . 323 . 133–40 . 2004 . 14659886 . 10.1016/j.gene.2003.09.013 . vanc. Yamada K . Shou Z . 3 . Mizutani . Tetsuya . Miyamoto . Kaoru .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . vanc. Hao T . Shaw C . 3 . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . 13709685 . free .
• de Andrade TG . Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster . Blood Cells Mol. Dis. . 37 . 2 . 82–90 . 2006 . 16952470 . 10.1016/j.bcmd.2006.07.003 . vanc. Peterson KR . Cunha AF . 3 . Moreira . Luciana Sarmento . Fattori . André . Saad . Sara T.O. . Costa . Fernando Ferreira .
• Liu G . ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome . J. Biol. Chem. . 281 . 51 . 39681–92 . 2007 . 17056598 . 10.1074/jbc.M606664200 . vanc. Clement LC . Kanwar YS . 3 . Avila-Casado . C. . Chugh . S. S. . free .
• Hu S . Expression of zinc-fingers and homeoboxes 2 in hepatocellular carcinogenesis: a tissue microarray and clinicopathological analysis . Neoplasma . 54 . 3 . 207–11 . 2007 . 17447851 . vanc. Zhang M . Lv Z . 3 . Bi . J . Dong . Y . Wen . J .

Notes and References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 5 . 6 . 355–64 . May 1999 . 10048485 . 10.1093/dnares/5.6.355 . free .
2. Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K . Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor . Biochem J . 373 . Pt 3 . 747–57 . Jul 2003 . 12741956 . 1223552 . 10.1042/BJ20030171 .
3. Web site: Entrez Gene: ZHX2 zinc fingers and homeoboxes 2.