ZHX1 explained

Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.^{[1] [2]}

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.^[2]

Interactions

ZHX1 has been shown to interact with NFYA.^[3]

Further reading

• Yamada K, Osawa H, Granner DK . Identification of proteins that interact with NF-YA . FEBS Letters . 460 . 1 . 41–5 . October 1999 . 10571058 . 10.1016/S0014-5793(99)01311-3 . 28576187 .
• Hirano S, Yamada K, Kawata H, Shou Z, Mizutani T, Yazawa T, Kajitani T, Sekiguchi T, Yoshino M, Shigematsu Y, Mayumi M, Miyamoto K . 6 . Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer . Gene . 290 . 1–2 . 107–14 . May 2002 . 12062805 . 10.1016/S0378-1119(02)00553-X .
• Yamada K, Kawata H, Matsuura K, Shou Z, Hirano S, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K . 6 . Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1) . Biochemical and Biophysical Research Communications . 297 . 2 . 368–74 . September 2002 . 12237128 . 10.1016/S0006-291X(02)02203-9 .
• Yamada K, Kawata H, Shou Z, Hirano S, Mizutani T, Yazawa T, Sekiguchi T, Yoshino M, Kajitani T, Miyamoto K . 6 . Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3 . The Biochemical Journal . 373 . Pt 1 . 167–78 . July 2003 . 12659632 . 1223464 . 10.1042/BJ20021866 .
• Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K . 6 . Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor . The Biochemical Journal . 373 . Pt 3 . 747–57 . August 2003 . 12741956 . 1223552 . 10.1042/BJ20030171 .
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . January 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . 6 . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–16 . June 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . 6 . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE . 6 . A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease . Molecular Cell . 15 . 6 . 853–65 . September 2004 . 15383276 . 10.1016/j.molcel.2004.09.016 . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . 6 . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . September 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . free . 11858/00-001M-0000-0010-8592-0 . free .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . 6 . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . free .
• Liu G, Clement LC, Kanwar YS, Avila-Casado C, Chugh SS . ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome . The Journal of Biological Chemistry . 281 . 51 . 39681–92 . December 2006 . 17056598 . 10.1074/jbc.M606664200 . free .
• Kim SH, Park J, Choi MC, Kim HP, Park JH, Jung Y, Lee JH, Oh DY, Im SA, Bang YJ, Kim TY . 6 . Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression . Biochemical and Biophysical Research Communications . 355 . 2 . 318–23 . April 2007 . 17303076 . 10.1016/j.bbrc.2007.01.187 .

Notes and References

1. Yamada K, Printz RL, Osawa H, Granner DK . Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y . Biochemical and Biophysical Research Communications . 261 . 3 . 614–21 . August 1999 . 10441475 . 10.1006/bbrc.1999.1087 . 35415109 .
2. Web site: Entrez Gene: ZHX1 zinc fingers and homeoboxes 1.
3. Yamada K, Osawa H, Granner DK . Identification of proteins that interact with NF-YA . FEBS Letters . 460 . 1 . 41–5 . October 1999 . 10571058 . 10.1016/S0014-5793(99)01311-3 . 28576187 .