ZFYVE26 explained
Zinc finger, FYVE domain containing 26 is a protein that in humans is encoded by the ZFYVE26 gene.[1]
Function
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15.[1]
References
Further reading
- Elleuch N, Bouslam N, Hanein S, Lossos A, Hamri A, Klebe S, Meiner V, Birouk N, Lerer I, Grid D, Bacq D, Tazir M, Zelenika D, Argov Z, Durr A, Yahyaoui M, Benomar A, Brice A, Stevanin G . Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families . Neurogenetics . 8 . 4 . 307–15 . Nov 2007 . 17661097 . 10.1007/s10048-007-0097-x . 25209385 .
- Boukhris A, Stevanin G, Feki I, Denis E, Elleuch N, Miladi MI, Truchetto J, Denora P, Belal S, Mhiri C, Brice A . Hereditary spastic paraplegia with mental impairment and thin corpus callosum in Tunisia: SPG11, SPG15, and further genetic heterogeneity . Archives of Neurology . 65 . 3 . 393–402 . Mar 2008 . 18332254 . 10.1001/archneur.65.3.393 . free .
- Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H . A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis . PLOS ONE . 6 . 3 . e17086 . 2011 . 21455500 . 3063775 . 10.1371/journal.pone.0017086 . 2011PLoSO...617086S . free .
- Goizet C, Boukhris A, Maltete D, Guyant-Maréchal L, Truchetto J, Mundwiller E, Hanein S, Jonveaux P, Roelens F, Loureiro J, Godet E, Forlani S, Melki J, Auer-Grumbach M, Fernandez JC, Martin-Hardy P, Sibon I, Sole G, Orignac I, Mhiri C, Coutinho P, Durr A, Brice A, Stevanin G . SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum . Neurology . 73 . 14 . 1111–9 . Oct 2009 . 19805727 . 10.1212/WNL.0b013e3181bacf59 . 39444163 .
- Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H . PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody . Nature Cell Biology . 12 . 4 . 362–71 . Apr 2010 . 20208530 . 10.1038/ncb2036 . 10852/28044 . 2765716 . free .
- Schüle R, Schlipf N, Synofzik M, Klebe S, Klimpe S, Hehr U, Winner B, Lindig T, Dotzer A, Riess O, Winkler J, Schöls L, Bauer P . Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia . Journal of Neurology, Neurosurgery, and Psychiatry . 80 . 12 . 1402–4 . Dec 2009 . 19917823 . 10.1136/jnnp.2008.167528 . 23251702 .
- Murmu RP, Martin E, Rastetter A, Esteves T, Muriel MP, El Hachimi KH, Denora PS, Dauphin A, Fernandez JC, Duyckaerts C, Brice A, Darios F, Stevanin G . Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia . Molecular and Cellular Neurosciences . 47 . 3 . 191–202 . Jul 2011 . 21545838 . 10.1016/j.mcn.2011.04.004 . 5450391 .
- Hanein S, Martin E, Boukhris A, Byrne P, Goizet C, Hamri A, Benomar A, Lossos A, Denora P, Fernandez J, Elleuch N, Forlani S, Durr A, Feki I, Hutchinson M, Santorelli FM, Mhiri C, Brice A, Stevanin G . Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome . American Journal of Human Genetics . 82 . 4 . 992–1002 . Apr 2008 . 18394578 . 2427184 . 10.1016/j.ajhg.2008.03.004 .
- Hughes CA, Byrne PC, Webb S, McMonagle P, Patterson V, Hutchinson M, Parfrey NA . SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q . Neurology . 56 . 9 . 1230–3 . May 2001 . 11342696 . 10.1212/wnl.56.9.1230 . 31185837 .
Notes and References
- Web site: Entrez Gene: Zinc finger, FYVE domain containing 26 .
