ZFYVE16 explained

Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.^{[1] [2]}

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004).[supplied by OMIM]

In melanocytic cells ZFYVE16 gene expression may be regulated by MITF.^[3]

Interactions

ZFYVE16 has been shown to interact with TOM1.^[4]

Further reading

• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . 6 . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 4 . 2 . 141–50 . April 1997 . 9205841 . 10.1093/dnares/4.2.141 . free .
• Seet LF, Liu N, Hanson BJ, Hong W . Endofin recruits TOM1 to endosomes . The Journal of Biological Chemistry . 279 . 6 . 4670–9 . February 2004 . 14613930 . 10.1074/jbc.M311228200 . free .
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry . Analytical Chemistry . 76 . 10 . 2763–72 . May 2004 . 15144186 . 10.1021/ac035352d .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . 6 . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . July 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . 6 . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nature Biotechnology . 23 . 1 . 94–101 . January 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . 6 . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Zhao BM, Hoffmann FM . Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA . Molecular Biology of the Cell . 17 . 9 . 3819–31 . September 2006 . 16775010 . 1556379 . 10.1091/mbc.E05-10-0990 .
• Chen YG, Wang Z, Ma J, Zhang L, Lu Z . Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling . The Journal of Biological Chemistry . 282 . 13 . 9688–95 . March 2007 . 17272273 . 10.1074/jbc.M611704200 . free .
• Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP . 6 . Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells . Proteomics . 7 . 14 . 2384–97 . July 2007 . 17570516 . 10.1002/pmic.200600968 . 23944956 .

Notes and References

1. Seet LF, Hong W . Endofin, an endosomal FYVE domain protein . The Journal of Biological Chemistry . 276 . 45 . 42445–54 . November 2001 . 11546807 . 10.1074/jbc.M105917200 . free .
2. Web site: Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16.
3. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E . 6 . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell & Melanoma Research . 21 . 6 . 665–76 . December 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . 24698373 . free .
4. Seet LF, Liu N, Hanson BJ, Hong W . Endofin recruits TOM1 to endosomes . The Journal of Biological Chemistry . 279 . 6 . 4670–9 . February 2004 . 14613930 . 10.1074/jbc.M311228200 . free .