ZFYVE1 explained

Zinc finger FYVE domain-containing protein 1 is a protein that in humans is encoded by the ZFYVE1 gene.^{[1] [2] [3]}

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution.Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.^[3]

Further reading

• Nagase T, Kikuno R, Nakayama M, etal . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 4 . 273–81 . 2001 . 10997877 . 10.1093/dnares/7.4.271. free .
• Ridley SH, Ktistakis N, Davidson K, etal . FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. . J. Cell Sci. . 114 . Pt 22 . 3991–4000 . 2002 . 10.1242/jcs.114.22.3991 . 11739631 .
• Krugmann S, Anderson KE, Ridley SH, etal . Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. . Mol. Cell . 9 . 1 . 95–108 . 2002 . 11804589 . 10.1016/S1097-2765(02)00434-3 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Heilig R, Eckenberg R, Petit JL, etal . The DNA sequence and analysis of human chromosome 14. . Nature . 421 . 6923 . 601–7 . 2003 . 12508121 . 10.1038/nature01348 . 2003Natur.421..601H . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wan D, Gong Y, Qin W, etal . Large-scale cDNA transfection screening for genes related to cancer development and progression. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842 . 2004PNAS..10115724W . free .

Notes and References

1. Derubeis AR, Young MF, Jia L, Robey PG, Fisher LW . Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library . Gene . 255 . 2 . 195–203 . Nov 2000 . 11024279 . 10.1016/S0378-1119(00)00303-6 .
2. Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM . Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi . Biochem J . 355 . Pt 1 . 113–21 . Mar 2001 . 11256955 . 1221718 . 10.1042/0264-6021:3550113 .
3. Web site: Entrez Gene: ZFYVE1 zinc finger, FYVE domain containing 1.