ZC3HAV1 explained

Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene.^{[1] [2] [3]}

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and at least four isoform variants have been described.^[4]

Further reading

• Yu Y, Zhang C, Zhou G, etal . Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. . Genome Res. . 11 . 8 . 1392–403 . 2001 . 11483580 . 10.1101/gr.175501 . 311073 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S .
• Bick MJ, Carroll JW, Gao G, etal . Expression of the zinc-finger antiviral protein inhibits alphavirus replication. . J. Virol. . 77 . 21 . 11555–62 . 2003 . 14557641 . 10.1128/JVI.77.21.11555-11562.2003 . 229374 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• MacDonald MR, Machlin ES, Albin OR, Levy DE . The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses. . J. Virol. . 81 . 24 . 13509–18 . 2007 . 17928353 . 10.1128/JVI.00402-07 . 2168828 .

Notes and References

1. Gao G, Guo X, Goff SP . Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein . Science . 297 . 5587 . 1703–6 . Sep 2002 . 12215647 . 10.1126/science.1074276 . 42188205 .
2. Katoh M, Katoh M . Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31 . Int J Oncol . 23 . 2 . 541–7 . Jul 2003 . 12851707 . 10.3892/ijo.23.2.541.
3. Web site: Entrez Gene: ZC3HAV1 zinc finger CCCH-type, antiviral 1.
4. Ficarelli . Mattia . Neil . Stuart J.D. . Swanson . Chad M. . Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System . Annual Review of Virology . 29 September 2021 . 8 . 1 . 265–283. free . 10.1146/annurev-virology-091919-104213 . 34129371 . 2327-056X.