ZBTB17 explained

Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.^[1]

Interactions

ZBTB17 has been shown to interact with TOPBP1,^[2] Host cell factor C1^[3] and Myc.^{[4] [5]}

Further reading

• Lichter P, Bray P, Ried T, Dawid IB, Ward DC . Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes . Genomics . 13 . 4 . 999–1007 . Aug 1992 . 1505991 . 10.1016/0888-7543(92)90013-I .
• Bray P, Lichter P, Thiesen HJ, Ward DC, Dawid IB . Characterization and mapping of human genes encoding zinc finger proteins . Proceedings of the National Academy of Sciences of the United States of America . 88 . 21 . 9563–7 . Nov 1991 . 1946370 . 52758 . 10.1073/pnas.88.21.9563 . 1991PNAS...88.9563B . free .
• Tommerup N, Vissing H . Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders . Genomics . 27 . 2 . 259–64 . May 1995 . 7557990 . 10.1006/geno.1995.1040 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R . Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA . Mechanisms of Development . 65 . 1–2 . 3–17 . Jul 1997 . 9256341 . 10.1016/S0925-4773(97)00032-4 . 11835268 .
• Book: Schneider A, Peukert K, Eilers M, Hänel F . Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc . Current Topics in Microbiology and Immunology . C-Myc in B-Cell Neoplasia . 224 . 137–46 . 1997 . 9308237 . 10.1007/978-3-642-60801-8_14 . 978-3-642-64560-0 .
• Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M . An alternative pathway for gene regulation by Myc . The EMBO Journal . 16 . 18 . 5672–86 . Sep 1997 . 9312026 . 1170199 . 10.1093/emboj/16.18.5672 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Sui D, Wilson JE . Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase . Archives of Biochemistry and Biophysics . 382 . 2 . 262–74 . Oct 2000 . 11068878 . 10.1006/abbi.2000.2019 .
• Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M . Repression of p15INK4b expression by Myc through association with Miz-1 . Nature Cell Biology . 3 . 4 . 392–9 . Apr 2001 . 11283613 . 10.1038/35070076 . 12696178 .
• Ziegelbauer J, Shan B, Yager D, Larabell C, Hoffmann B, Tjian R . Transcription factor MIZ-1 is regulated via microtubule association . Molecular Cell . 8 . 2 . 339–49 . Aug 2001 . 11545736 . 10.1016/S1097-2765(01)00313-6 . free .
• Tussie-Luna MI, Michel B, Hakre S, Roy AL . The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I . The Journal of Biological Chemistry . 277 . 45 . 43185–93 . Nov 2002 . 12193603 . 10.1074/jbc.M207635200 . free .
• Piluso D, Bilan P, Capone JP . Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1 . The Journal of Biological Chemistry . 277 . 48 . 46799–808 . Nov 2002 . 12244100 . 10.1074/jbc.M206226200 . free .
• Zhang H, Li Z, Viklund EK, Strömblad S . P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration . The Journal of Cell Biology . 158 . 7 . 1287–97 . Sep 2002 . 12356872 . 2173231 . 10.1083/jcb.200207008 .
• Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M . Negative regulation of the mammalian UV response by Myc through association with Miz-1 . Molecular Cell . 10 . 3 . 509–21 . Sep 2002 . 12408820 . 10.1016/S1097-2765(02)00633-0 . free .
• Wu S, Cetinkaya C, Munoz-Alonso MJ, von der Lehr N, Bahram F, Beuger V, Eilers M, Leon J, Larsson LG . Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter . Oncogene . 22 . 3 . 351–60 . Jan 2003 . 12545156 . 10.1038/sj.onc.1206145 . 903258 .
• Bowen H, Lapham A, Phillips E, Yeung I, Alter-Koltunoff M, Levi BZ, Perry VH, Mann DA, Barton CH . Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1 . The Journal of Biological Chemistry . 278 . 38 . 36017–26 . Sep 2003 . 12840021 . 10.1074/jbc.M304301200 . free .
• Sakurai T, Itoh K, Higashitsuji H, Nagao T, Nonoguchi K, Chiba T, Fujita J . A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells . The Journal of Biological Chemistry . 279 . 15 . 15505–14 . Apr 2004 . 14739298 . 10.1074/jbc.M310437200 . free . 2433/147540 . free .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–23 . Jul 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .

Notes and References

1. Web site: Entrez Gene: ZBTB17 zinc finger and BTB domain containing 17.
2. Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M . Negative regulation of the mammalian UV response by Myc through association with Miz-1 . Molecular Cell . 10 . 3 . 509–21 . Sep 2002 . 12408820 . 10.1016/S1097-2765(02)00633-0 . free .
3. Piluso D, Bilan P, Capone JP . Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1 . The Journal of Biological Chemistry . 277 . 48 . 46799–808 . Nov 2002 . 12244100 . 10.1074/jbc.M206226200 . free .
4. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M . Repression of p15INK4b expression by Myc through association with Miz-1 . Nature Cell Biology . 3 . 4 . 392–9 . Apr 2001 . 11283613 . 10.1038/35070076 . 12696178 .
5. Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M . An alternative pathway for gene regulation by Myc . The EMBO Journal . 16 . 18 . 5672–86 . Sep 1997 . 9312026 . 1170199 . 10.1093/emboj/16.18.5672 .