ZBTB1 explained

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.[1]

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.[2] [3]

Notes and References

  1. Web site: Entrez Gene: Zinc finger and BTB domain containing 1 .
  2. Siggs OM, Li X, Xia Y, Beutler B . ZBTB1 is a determinant of lymphoid development . The Journal of Experimental Medicine . 209 . 1 . 19–27 . January 2012 . 22201126 . 3260866 . 10.1084/jem.20112084 .
  3. Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM . Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development . Journal of Immunology . 189 . 3 . 1253–64 . August 2012 . 22753936 . 3401355 . 10.4049/jimmunol.1200623 .

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