| Yuriy Istomin | |
| Fullname: | Yuriy Vasylyovych Istomin |
| Birth Date: | 1944 7, df=yes |
| Birth Place: | Kharkiv, Ukrainian SSR, USSR |
| Position: | Defender |
| Youthyears1: | 1963 |
| Youthclubs1: | Avangard Kharkiv |
| Years1: | 1964–1965 |
| Years2: | 1966–1974 |
| Years3: | 1975 |
| Clubs3: | SK Lutsk |
| Caps2: | 206 |
| Goals2: | 1 |
| Nationalyears1: | 1967–1972 |
| Nationalteam1: | USSR |
| Nationalcaps1: | 34 |
| Nationalgoals1: | 0 |
Yuriy Vasylyovych Istomin (Юрій Васильович Істомин, Russian: Юрий Васильевич Истомин, Yuriy Vasilyevich Istomin; 3 July 1944 – 6 February 1999) was a Soviet Ukrainian footballer.
He earned 34 caps for the USSR national football team, and participated in UEFA Euro 1968 and UEFA Euro 1972. He also earned a bronze medal in football at the 1972 Summer Olympics.