Yuet Wai Kan Explained

Yuet Wai Kan
Honorific-Suffix:,
Birth Date:11 June 1936[1]
Birth Place:British Hong Kong[2]
Nationality:American
Fields:Human genetics
Hematology
Workplaces:Peter Bent Brigham Hospital
University of Pittsburgh
Massachusetts Institute of Technology
McGill University
University of Pennsylvania
Boston Children's Hospital
Harvard University
San Francisco General Hospital
Howard Hughes Medical Institute
University of California, San Francisco
Education:University of Hong Kong (MBBS)
Known For:Research of single-nucleotide polymorphism
Prenatal testing of blood disease
Awards:William Allan Award
Canada Gairdner International Award
Albert Lasker Clinical Medical Research Award
Shaw Prize in Life Science & Medicine[3]
Spouse:Alvera Limauro Kan[4]
Children:2
Module:
T:簡悅威
S:简悦威
J:Gaan2 Jyut6 Wai1
Y:Gáan Yuht Wāi

Yuet Wai Kan (; born June 11, 1936), is a Chinese-American geneticist and hematologist. He is the current Louis K. Diamond Chair in Hematology[5] [6] and a Professor Emeritus at the University of California, San Francisco.[7] He is a former president of the American Society of Hematology.[8]

Early life and education

Kan is of Shunde, Guangdong, descent,[9] and was born in Hong Kong to the prominent Kan family. His father, Tong Po Kan,[10] was a co-founder of Bank of East Asia,[9] and had 14 children;[11] Kan is the youngest. Kan's brother, Yuet-keung Kan, was the Senior Unofficial Member of the Legislative Council of Hong Kong and the Executive Council of Hong Kong, and a former chairman of the Bank of East Asia.[12]

Kan started his education at True Light Elementary School, not long before the Japanese occupation of Hong Kong during World War II. He entered Wah Yan College, Hong Kong after the war and graduated in 1952.[2] He then followed his father's wish and studied medicine in the University of Hong Kong (HKU), staying at the residence of Morrison Hall[13] and obtaining his Bachelor of Medicine, Bachelor of Surgery degree in 1958, with a distinction in Social Medicine, Medicine, Surgery and Obstetrics and Gynecology.[2] [3] [14] [15]

The University of Hong Kong awarded Kan a Doctor of Science in 1980.[3] [14]

Career

After spending 2 years at Queen Mary Hospital for residency and internship, at the advice of David Todd, a professor at the HKU Department of Medicine,[16] Kan went to the United States in 1960 to work and be trained in various North American institutions. He first went to Peter Bent Brigham Hospital in Boston (now part of Brigham and Women's Hospital)[17] to work and learn hematology under Frank H. Gardner, during which he became interested in research.[2] He then moved to the University of Pittsburgh to finish his clinical training and residency under Jack Myers,[2] [18] and then joined Vernon Ingram at the Massachusetts Institute of Technology to learn about hemoglobin.[13] Kan then joined Royal Victoria Hospital at McGill University in Montreal as a fellow in hematology under Louis Lowenstein.[13] [19] He became interested in thalassemia after attending to an infant with alpha-thalassemia.[19]

After the fellowship, Kan briefly teamed up with Frank H. Gardner again at the University of Pennsylvania, to which Gardner recently moved. He moved again in 1970, when a former colleague of his at Peter Bent Brigham Hospital invited him to study thalassemia at Boston Children's Hospital,[2] and became an assistant professor at Harvard University.[20] In 1972, Kan went to San Francisco General Hospital to become the Chief of Hematology Service, and was, at the same time, appointed an associate professor at the University of California, San Francisco (UCSF).[15] In 1976, he became an Investigator at the Howard Hughes Medical Institute, a position from which he retired in 2003.[21] Kan was promoted to full professor in 1977 at the Department of Medicine of UCSF, and was cross-appointed to the Department of Biochemistry and Biophysics in 1979.[15] In 1983, he was appointed Head of the Division of Genetics and MolecularHematology at the Department of Medicine,[20] and became the Louis K. Diamond Chair in Hematology.[15] [22]

Kan sat on the President's Committee on the National Medal of Science, which reviews nominations for the award, from 1988 to 1990,[23] and was the President of the American Society of Hematology in 1990.[24] [25] He was also the President of the Society of Chinese Bioscientists in America from 1998 to 1999,[26] and was the Chairman of the Board of Trustees of the Croucher Foundation, Hong Kong, from 1991 to 2011.[27]

In 1993, Kan was appointed to head the newly established Gene Therapy Core Center at UCSF.[28]

Kan has also served on the Committee on Human Rights of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine (now National Academy of Medicine) from 2000 until at least 2008,[29] [30] [31] and was the Director of the Institute of Molecular Biology at the University of Hong Kong from 1990 to 1994,[29] [32] which was dissolved in 2005.[33]

Since 1994,[16] Kan has been an advisor at the Hong Kong-based Qiu Shi Science and Technologies Foundation, which supports science in China.[34]

Research

Kan is best known for his research in the etiology of thalassemia, and has significant contribution to the prenatal testing of hemoglobinopathy and the research in single-nucleotide polymorphisms (SNPs).[35] [36]

Kan and his collaborators found the deletion of a gene was the cause of alpha-thalassemia,[37] the first demonstration of its kind for any disease.[15] He was also the first to establish that a single DNA mutation could lead to a human disease, and the first to diagnose a human disease using DNA.[38] His 1979 report on the cause of beta-thalassemia established the disease-causing ability of SNPs, where he found that a nonsense mutation, a type of point mutation, led to the truncation of the beta chains of hemoglobin.[39] [40]

In prenatal testing research, he discovered, in 1972, that hemoglobin protein chains could be isolated from fetal blood, and the presence of abnormal hemoglobin chains signified sickle cell disease, allowing for the detection of the disease before birth.[41] Then, building on his finding that alpha-thalassemia was caused by a gene deletion, he designed a DNA-based test for the deletion,[42] the first time a DNA test was used for diagnosing a human condition.[2] In 1978, he discovered a SNP next to the HBB gene that is associated with the HBB mutation that causes sickle cell disease. Digesting this DNA sequence with special enzymes (known as restriction enzymes) yielded specific DNA fragments, the sets of which varied according to the SNP variation and, by association, the presence of the sickle cell disease-causing mutation,[43] [44] suggesting an indirect diagnostic method for the disease and marking the first use of SNPs in genetic linkage analysis of human diseases.[2]

In the recent decade, Kan has applied gene therapy and genome editing techniques to treat thalassemia, sickle cell disease and blood cancer.[45] [46] [47] [48]

Personal life

Kan married Alvera Limauro in 1964 in Boston.[13] They met each other on their first day at Frank H. Gardner's lab at the Peter Bent Brigham Hospital (now part of Brigham and Women's Hospital)[17] in Boston, but did not started dating 2 years later.[13] They have 2 daughters, Susan, a lawyer in San Francisco,[4] and Deborah,[4] a former Wall Street Journal reporter in Hong Kong and the founder an online information platform for Alzheimer's disease called Being Patient,[49] [50] and 5 grandchildren.[13] As of 2019, Kan and his wife live in San Francisco.[13]

Honors and awards

The Y W Kan Professorship in Natural Sciences at the University of Hong Kong was created in Kan's honor.[51]

Notes and References

  1. Web site: Kan Yuet-wai . Chinese Child Health International . December 7, 2021 . https://web.archive.org/web/20041103130106/http://www.cchi.com.hk/ourteam/YuetWaiKan/index.htm . November 3, 2004.
  2. Web site: Autobiography of Yuet-Wai Kan . . December 27, 2021 . https://web.archive.org/web/20211227162259/https://www.shawprize.org/prizes-and-laureates/life-science-and-medicine/2004/autobiography-of-yuet-wai-kan . December 27, 2021.
  3. Web site: Prof Yuet-Wai KAN . Hong Kong Academy of Sciences . December 27, 2021 . https://web.archive.org/web/20211227161023/http://www.ashk.org.hk/en/ourMembers/details/37 . December 27, 2021.
  4. Web site: Heroes in Health and Healing: Yuet Wai Kan, Leader in Human Genetics . University of California, San Francisco . February 12, 2022 . https://web.archive.org/web/20220212152309/http://ucsf150.ucsf.edu/#!/#Present . February 12, 2022.
  5. Web site: Yuet Wai Kan, MBBS, DSc, FRS . . https://web.archive.org/web/20200730045906/https://humangenetics.ucsf.edu/kan-yuet-wai/ . July 30, 2020 . December 28, 2021.
  6. Web site: Y.W. Kan, MD, FRS . University of California, San Francisco . December 28, 2021 . https://web.archive.org/web/20211228161212/https://cancer.ucsf.edu/people/kan.yuet . December 28, 2021.
  7. Web site: Yuet Kan, MD . University of California, San Francisco . December 28, 2021 . https://web.archive.org/web/20211228160255/https://profiles.ucsf.edu/yuet.kan . December 28, 2021.
  8. Web site: Yuet Wai Kan . . December 28, 2021 . https://web.archive.org/web/20211228161212/https://www.hematology.org/about/history/legends/yuet-wai-kan-bio . December 28, 2021.
  9. Book: 馮 . 邦彥 . 香港華資財團(1841-2020) . 2020 . Joint Publishing (Hong Kong) . . 9789620447068 . 85 . https://web.archive.org/web/20220130030323/https://books.google.com/books?id=8XcWEAAAQBAJ . January 30, 2022 . December 30, 2021 . zh. 銀行翹楚：東亞與恒生.
  10. News: 失去信心 見完鄧小平淡出政壇 . December 30, 2021 . . September 23, 2012 . https://web.archive.org/web/20200302185415/https://hk.news.appledaily.com/local/daily/article/20120923/18022812 . March 2, 2020 . zh.
  11. Book: 鄭 . 宏泰 . 黃 . 紹倫 . 富不過三代的假象與現實：家業長青的例子和特徵 . 商城記──香港家族企業縱橫談 . 2014 . Chung Hwa Book Company (Hong Kong) . Hong Kong . 274 . 9789888310470 . https://web.archive.org/web/20220129152219/https://books.google.com/books?id=Gq8QBgAAQBAJ . January 29, 2022 . December 30, 2021 . zh.
  12. News: 政商強人 倡議成立廉署 簡悅強走完99年人生 . December 30, 2021 . Apple Daily . September 23, 2012 . https://web.archive.org/web/20200302184716/https://hk.news.appledaily.com/local/daily/article/20120923/18022808 . March 2, 2020.
  13. Book: Ing . Todd S . Lau . Keith K . Chan . Joseph M . Tang . Hon-Lok . Hadsell . Angela T . Chan . Laurence K . Nobel and Lasker Laureates of Chinese Descent: In Literature and Science . 2019 . . . 9789814704601 . January 29, 2022 . https://web.archive.org/web/20220129151733/https://www.worldscientific.com/worldscibooks/10.1142/9716 . January 29, 2022 . Yuet Wai Kan 簡悅威 1991 Albert Lasker Clinical Medical. 10.1142/9716 . 164035712 .
  14. Web site: KAN Yuet Wai - Biography . . January 1, 2022 . https://web.archive.org/web/20220101145321/https://www4.hku.hk/hongrads/graduates/hon-m-d-hon-d-sc-m-b-b-s-d-sc-f-r-s-yuet-wai-kan-kan-yuet-wai . January 1, 2022.
  15. Web site: KAN Yuet Wai - Citation . University of Hong Kong . January 1, 2022 . https://web.archive.org/web/20220101145538/https://www4.hku.hk/hongrads/citations/hon-m-d-hon-d-sc-m-b-b-s-d-sc-f-r-s-yuet-wai-kan-kan-yuet-wai . January 1, 2022.
  16. Mackay . John . Professor Yuet Wai Kan . 2004 . Synapse . . January 29, 2022.
  17. Web site: The History of Brigham and Women's Hospital . . January 1, 2022 . https://web.archive.org/web/20220101151650/https://www.brighamandwomens.org/about-bwh/bwh-history . January 1, 2022.
  18. Bittel . Jason . Yuet Wai Kan Wants to Reprogram Blood . 2015 . PittMed . . January 1, 2022 . https://web.archive.org/web/20220101160743/https://www.pittmed.health.pitt.edu/story/yuet-wai-kan-wants-reprogram-blood . January 1, 2022.
  19. Hampton . Tracy . Yuet Wai Kan, MD . . 2006 . 295 . 9 . 991 . 10.1001/jama.295.9.991 . 16507792 . January 2, 2022.
  20. Kazazian Jr. . Haig H. . The William Allan Memorial Award presented to Yuet Wai Kan . . 1986 . 38 . 1 . 1–3 . 3511682 . 1684715 .
  21. Web site: Yuet Wai Kan, MD, DSc . . January 5, 2022 . https://web.archive.org/web/20220105040153/https://www.hhmi.org/scientists/yuet-wai-kan . January 5, 2022.
  22. Book: UCSF's Y. W. Kan Appointed to Louis K. Diamond Chair in Hematology . UCSF News . https://web.archive.org/web/20220130030931/https://books.google.com/books?id=8fY2AQAAMAAJ . January 30, 2022 . January 10, 2022 . University of California, San Francisco . . 1983.
  23. Book: UCSF geneticist Appointed to White House Committee . UCSF News . https://web.archive.org/web/20220129152512/https://books.google.com/books?id=cfE2AQAAMAAJ . January 29, 2022 . January 20, 2022 . University of California, San Francisco . 1988 . San Francisco.
  24. Web site: Past Presidents . American Society of Hematology . January 12, 2022 . https://web.archive.org/web/20220112153157/https://www.hematology.org/about/history/past-presidents . January 12, 2022.
  25. Web site: Yuet Wai Kan . American Society of Hematology . September 22, 2008 . https://web.archive.org/web/20080922015449/http://www.hematology.org/education/legends/Kan/ . September 22, 2008.
  26. Web site: Past Presidents . Society of Chinese Bioscientists in America . January 20, 2022 . https://web.archive.org/web/20220120042655/https://www.scbasociety.org/past-presidents . January 20, 2022.
  27. Book: Croucher Foundation Seventh Report 2011 - 2015 . 2016 . Croucher Foundation . . 16 . January 20, 2022 . Professor Yuet Wai Kan, Trustee and Chairman of the Croucher Foundation . https://web.archive.org/web/20220120044313/https://croucher.org.hk/wp-content/uploads/2016/09/Seventh-Report.pdf . January 20, 2022.
  28. News: Kan to head new Gene Therapy Core Center at UCSF . January 10, 2022 . Synapse . 38 . University of California, San Francisco . October 21, 1993 . https://web.archive.org/web/20220112153620/https://cdnc.ucr.edu/?a=d&d=ucsf19931021-01.2.5&e=-------en--20--1--txt-txIN--------1 . January 12, 2022.
  29. 2006 SCBA Keynote Speakers . 2006 . 10 . 13 . Society of Chinese Bioscientists in America . Asia Pacific Biotech News. January 20, 2022 . https://web.archive.org/web/20220120042428/http://www.asiabiotech.com/10/1013/0028_0039.pdf . January 20, 2022.
  30. Web site: Yuet Wai Kan, CHR Member . November 25, 2008 . https://web.archive.org/web/20081109170243/http://www7.nationalacademies.org/humanrights/CHR_Member_Kan.html . November 9, 2008 .
  31. Web site: THE NATIONAL ACADEMIES . . January 4, 2022 . November 26, 2007 . https://web.archive.org/web/20220104014150/https://www7.nationalacademies.org/humanrights/cs/groups/chrsite/documents/webpage/chr_170228.pdf . January 4, 2022.
  32. News: Yuet Wai Kan An Interview . January 10, 2022 . Synapse . 36 . University of California, San Francisco . May 21, 1992 . https://web.archive.org/web/20220110085852/https://cdnc.ucr.edu/?a=d&d=ucsf19920521-01.2.30&srpos=1&e=-------en--20-ucsf-1--txt-txIN-------1-1 . January 10, 2022.
  33. Web site: Other Departments, Centres, Units and School . University of Hong Kong . 27 May 2022 . https://web.archive.org/web/20220527150038/https://www.cpao.hku.hk/cpao/terminology/other-departments-centres-units-school/m . 27 May 2022.
  34. Web site: Professor Yuet Wai KAN . Qiu Shi Science and Technologies Foundation . January 14, 2022 . https://web.archive.org/web/20220118093729/http://www.qiushi.org/index.php?m=content&c=index&a=show&catid=119&id=4 . January 18, 2022.
  35. Web site: An Essay on Prize One in Life Science and Medicine 2004 . The Shaw Prize Foundation . January 27, 2022 . https://web.archive.org/web/20220127002440/https://www.shawprize.org/prizes-and-laureates/life-science-and-medicine/2004/an-essay-on-prize-one-in-life-science-and-medicine-2004-ywk . January 27, 2022.
  36. Yuet-wai Kan, Louis K. Diamond Professor of Haematology, Medicine and Laboratory Medicine at UC San Francisco . October 30, 2004 . The University of Hong Kong Bulletin . University of Hong Kong . January 29, 2022 . 6 . 1 . https://web.archive.org/web/20220129032456/https://www4.hku.hk/pubunit/Bulletin/2004_Oct%286.1%29.pdf . January 29, 2022.
  37. Taylor . JM . Dozy . A . Kan . YW . Varmus . HE . Lieinjo . LE . Ganesan . J . Todd . D . Gene deletion as the cause of α thalassaemia: Genetic lesion in homozygous α thalassaemia (hydrops fetalis) . . 1974 . 251 . 5474 . 392–393 . 4424635 . January 26, 2022 . 10.1038/251392a0. 1974Natur.251..392T . 4154498 .
  38. News: Ravven . Wallace . UCSF genetics pioneer Y.W. Kan earns Lifetime Achievement Award . January 22, 2022 . University of California, San Francisco . July 21, 2006 . https://web.archive.org/web/20220122144505/https://www.ucsf.edu/news/2006/07/101879/ucsf-genetics-pioneer-yw-kan-earns-lifetime-achievement-award . January 22, 2022.
  39. Chang . Judy C. . Kan . Yuet Wai . β0 thalassemia, a nonsense mutation in man . . 1979 . 76 . 6 . 2886–2889 . 10.1073/pnas.76.6.2886 . 383714 . 88735 . 1979PNAS...76.2886C . January 26, 2022 . https://web.archive.org/web/20220126025520/https://www.pnas.org/content/pnas/76/6/2886.full.pdf . January 26, 2022. free .
  40. Web site: Yuet Wai Kan . November 25, 2008 . https://web.archive.org/web/20080922015449/http://www.hematology.org/education/legends/Kan/ . September 22, 2008.
  41. Kan . Yuet Wai . Dozy . Andrée M. . Alter . Blanche P. . Frigoletto . Fredric D. . Nathan . David G. . Detection of the Sickle Gene in the Human Fetus — Potential for Intrauterine Diagnosis of Sickle-Cell Anemia . . 1972 . 287 . 1 . 1–5 . 10.1056/NEJM197207062870101 . 5029215 . January 26, 2022.
  42. Kan . Yuet Wai . Golbus . Mitchell S. . Dozy . Andree M. . Prenatal Diagnosis of α-Thalassemia — Clinical Application of Molecular Hybridization . The New England Journal of Medicine . 1976 . 295 . 21 . 1165–1167 . 10.1056/NEJM197611182952104 . 980019 . January 27, 2022.
  43. Kan . Yuet Wai . Dozy . Andree M. . Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation . Proceedings of the National Academy of Sciences of the United States of America . 1978 . 75 . 11 . 5631–5635 . 10.1073/pnas.75.11.5631 . 281713 . https://web.archive.org/web/20220127010643/https://www.pnas.org/content/pnas/75/11/5631.full.pdf . January 27, 2022 . January 27, 2022 . 393021. 1978PNAS...75.5631K . free .
  44. Book: Cook-Deegan . Robert M. . The Gene Wars: Science, Politics, and the Human Genome . https://web.archive.org/web/20220130025620/https://dukespace.lib.duke.edu/dspace/handle/10161/8990 . January 30, 2022 . 1994 . . . 10161/8990 . 0393313999 . 34 . Mapping Our Genes.
  45. Chang . Judy C. . Lin . Ye . Kan . Yuet Wai . Correction of the sickle cell mutation in embryonic stem cells . Proceedings of the National Academy of Sciences of the United States of America . 2006 . 103 . 4 . 1036–1040 . 10.1073/pnas.0510177103 . 16407095 . January 28, 2022 . 1326143 . 2006PNAS..103.1036C . January 28, 2022 . https://web.archive.org/web/20220128020453/https://www.pnas.org/content/pnas/103/4/1036.full.pdf. free .
  46. Xie . Fei . Ye . Lin . Chang . Judy C. . Beyer . Ashley I. . Wang . Jiaming . Muench . Marcus O. . Kan . Yuet Wai . Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac . . 2014 . 24 . 9 . 1526–1533 . 10.1101/gr.173427.114 . 25096406 . January 28, 2022 . 4158758 . January 28, 2022 . https://web.archive.org/web/20220128022933/http://genome.cshlp.org/content/24/9/1526.long.
  47. Ye . Lin . Wang . Jiaming . Tan . Yuting . Beyer . Ashley I. . Xie . Fei . Muench . Marcus O. . Kan . Yuet Wai . Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia . Proceedings of the National Academy of Sciences of the United States of America . 2016 . 113 . 38 . 10661–10665 . 10.1073/pnas.1612075113 . 27601644 . 5035856 . 2016PNAS..11310661Y . free .
  48. Tan . Yu-Ting . Ye . Lin . Fei . Xie . Wang . Jiaming . Müschen . Markus . Chen . Sai-Juan . Kan . Yuet Wai . Liu . Han . CRISPR/Cas9-mediated gene deletion efficiently retards the progression of Philadelphia-positive acute lymphoblastic leukemia in a p210 BCR-ABL1T315I mutation mouse model . . 2020 . 105 . 5 . e232–e236 . 10.3324/haematol.2019.229013 . 31537693 . January 28, 2022 . 7193494 . January 28, 2022 . https://web.archive.org/web/20220128020815/https://haematologica.org/article/view/9409.
  49. Kan . Deborah . Why I Left Hong Kong: The Hidden Crisis of Covid-19 . AsiaGlobal Online . November 25, 2021 . https://web.archive.org/web/20220212152952/https://www.asiaglobalonline.hku.hk/why-i-left-hong-kong-hidden-crisis-covid-19 . February 12, 2022 . February 12, 2022.
  50. Web site: Being Patient . Being Patient . February 8, 2022 . https://web.archive.org/web/20220208233422/https://www.beingpatient.com/ . February 8, 2022.
  51. Web site: Y W Kan Professorship in Natural Sciences . University of Hong Kong . January 28, 2022 . https://web.archive.org/web/20220128014055/http://www.daao.hku.hk/ephku/en/Professorship-Detail/15-Y-W-Kan-Professorship-In-Natural-Sciences.html . January 28, 2022.

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