YqeY protein domain explained

Symbol:	YqeY
YqeY
Pfam:	PF09424
Pfam Clan:	CL0279
Interpro:	IPR019004
Scop:	1ng5

In molecular biology, YqeY is a type of protein domain of unknown function. It is thought to have a role in protein synthesis, facilitating the production of charged transfer RNA used in the process of translating mRNA into protein. It is present as a domain of glutaminyl-tRNA synthetase (GlnRS) in almost all eukaryotes.^[1]

Function

The YqeY domain has been found to be involved in the recognition of tRNA charged with the amino acid glutamine (tRNA-Gln). In some cases YqeY also increases the affinity of GlnRS for tRNA-Gln, but only when present in cis (that is, as part of the GlnRS polypeptide chain). However, the presence of YqeY as a standalone domain in organisms without GlnRS suggests that YqeY domains may have additional cellular functions.^[2]

Homology

This protein domain shares sequence homology with the C-terminal domain of GatB and GatE, the tRNA-binding subunits of bacterial and archaeal glutamine amidotransferases.^[2]

Notes and References

1. Hadd. A. Perona. JJ. Coevolution of specificity determinants in eukaryotic glutamyl- and glutaminyl-tRNA synthetases.. Journal of Molecular Biology. 23 October 2014. 426. 21. 3619–33. 25149203. 10.1016/j.jmb.2014.08.006.
2. Deniziak M, Sauter C, Becker HD, Paulus CA, Giegé R, Kern D . Deinococcus glutaminyl-tRNA synthetase is a chimer between proteins from an ancient and the modern pathways of aminoacyl-tRNA formation. . Nucleic Acids Res . 2007 . 35 . 5 . 1421–31 . 17284460 . 10.1093/nar/gkl1164 . 1865053 .