| Official Name: | Yokadouma |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Cameroon |
| Subdivision Type: | Country |
| Subdivision Name: | Cameroon |
| Subdivision Type1: | Province |
| Subdivision Name1: | East Province |
| Subdivision Type2: | Division |
| Subdivision Name2: | Boumba-et-Ngoko |
| Pushpin Map: | Cameroon |
| Population As Of: | 2012 |
| Population Total: | 24430 |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Coordinates: | 3.5167°N 18°W |
| Elevation M: | 560 |
Yokadouma is a town and Catholic bishopric in eastern Cameroon, lying near the border with the Central African Republic. It was an early French administrative centre.
During the colonial period, Yokadouma was the centre for a widespread but ill-fated immunisation campaign against sleeping sickness, known as 'lomidinisation'. The administration of the drug had little preventative benefit and in many cases the colonial doctors cut corners. In one incident on November 15, 1954, known as the "accident of Yokadouma", the French doctor misadministered the drug to such an extent that more than 300 people contracted gangrene and 32 more died. It has been described as "one of the most violent medical catastrophes in African history."[1]
Its Cathédrale Marie Reine de la Paix, dedicated in 2010 to Our Lady Queen of Peace, is the cathedral episcopal see of the Roman Catholic Diocese of Yokadouma (founded 1991).[2]