Yoda1 Explained

Yoda1 is a chemical compound which is the first agonist developed for the mechanosensitive ion channel PIEZO1. This protein is involved in regulation of blood pressure and red blood cell volume, and Yoda1 is used in scientific research in these areas.^{[1] [2] [3] [4] [5]}

See also

• Jedi1 and Jedi2

Notes and References

1. Syeda . Ruhma . Xu . Jie . Dubin . Adrienne E. . Coste . Bertrand . Mathur . Jayanti . Huynh . Truc . Matzen . Jason . Lao . Jianmin . Tully . David C. . Engels . Ingo H. . Petrassi . H. Michael . Schumacher . Andrew M. . Montal . Mauricio . Bandell . Michael . Patapoutian . Ardem . 2015 . Chemical activation of the mechanotransduction channel Piezo1 . doi . eLife . 4 . e07369 . 10.7554/eLife.07369 . free . 4456433 . 26001275 . 2652667 . free.
2. Cahalan . Stuart M. . Lukacs . Viktor . Ranade . Sanjeev S. . Chien . Shu . Bandell . Michael . Patapoutian . Ardem . 2015 . Piezo1 links mechanical forces to red blood cell volume . doi . eLife . 4 . e07370 . 10.7554/eLife.07370 . free . 4456639 . 26001274 . 15018525 . free.
3. Wang . ShengPeng . Chennupati . Ramesh . Kaur . Harmandeep . Iring . Andras . Wettschureck . Nina . Offermanns . Stefan . 2016 . Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release . Journal of Clinical Investigation . doi . 126 . 12 . 4527–4536 . 10.1172/JCI87343 . free . 5127677 . 27797339 . 38263363 . free.
4. Rapetti-Mauss . Raphaël . Picard . Véronique . Guitton . Corinne . Ghazal . Khaldoun . Proulle . Valérie . Badens . Catherine . Soriani . Olivier . Garçon . Loïc . Guizouarn . Hélène . 2017 . Red blood cell Gardos channel (KCNN4): The essential determinant of erythrocyte dehydration in hereditary xerocytosis . doi . Haematologica . 102 . 10 . e415–e418 . 10.3324/haematol.2017.171389 . free . 5622875 . 28619848 . 31756119 . free.
5. Book: Gnanasambandam . R. . Gottlieb . P. A. . Sachs . F. . The Kinetics and the Permeation Properties of Piezo Channels . 2017 . Gottlieb . Philip A. . Piezo Channels . Current Topics in Membranes . 79 . Academic Press . 275–307 . 10.1016/bs.ctm.2016.11.004 . 978-0-12-809389-4 . 28728821 . 3743286.