| Honorific-Prefix: | Rabbi |
| Yitzchok Ezrachi | |
| Rosh Yeshiva in Mir | |
| Synagogue: | Shul in Mattesdorf |
| Synagogueposition: | Rov |
| Yeshiva: | Mir yeshiva (Jerusalem) |
| Yeshivaposition: | Rosh yeshiva |
| Birth Name: | Yitzchok Ezrachi |
| Nationality: | Israeli |
| Denomination: | Haredi |
| Residence: | Jerusalem, Israel |
| Spouse: | daughter of Chaim Leib Shmuelevitz |
Yaakov Yitzchok Ezrachi (Hebrew: יצחק אזרחי; born August 1933) is a Rosh Yeshiva (dean) at the Mir Yeshiva in Jerusalem.
Ezrachi was born in Jerusalem to Yisrael Ezrachi and Hinda the daughter of Baruch Shlom, a graduate of the Knesses Yisrael Yeshiva in Slobodka who served as a rabbi in South Africa and was the grandson of Uri David Apiryon, rabbi of Žagarė in Lithuania and author of the book Apiryon David. He studied at the Mir Yeshiva.
Since 1979, he has serves as one of the rosh yeshivas of the Mir Yeshiva, next to Eliezer Yehuda Finkel.
Ezrachi is a son-in-law of Chaim Leib Shmuelevitz, also a former Rosh Yeshiva at the Mirrer Yeshiva. Ezrachi's brother was Baruch Mordechai Ezrachi, another prominent Haredi rabbi.