Ying Ge Explained

Ying Ge
Alma Mater:Cornell University
University of Peking
Workplaces:University of Wisconsin-Madison
Wyeth
Thesis Title:Top down characterization of proteins by electron capture dissociation and blackbody infrared radiative dissociation mass spectrometry
Thesis Url:http://www.worldcat.org/oclc/52791635
Thesis Year:2002

Ying Ge is a Chinese-American chemist who is a Professor of Cell and Regenerative Biology at the University of Wisconsin–Madison. Her research considers the molecular mechanisms that underpin cardiac disease. She has previously served on the board of directors of the American Society for Mass Spectrometry. In 2020 Ge was named on the Analytical Scientist Power List.

Early life and education

Ge was born in China. She attended Peking University for her undergraduate studies, where she studied chemistry.[1] After graduating in 1997 Ge moved to the United States, where she joined Cornell University as a doctoral student. Here she started to work on mass spectrometry, using electron-capture dissociation to study proteins.[2] She worked under the supervision of Tadhg Begley and Fred McLafferty. After completing her doctorate, Ge worked as a research scientist at Wyeth.

Research and career

Ge joined the University of Wisconsin–Madison as an assistant scientist, where she oversaw the mass spectrometry programme. She became an Associate Professor in 2015, and full Professor in 2019.[3]

Ge develops high-resolution mass spectrometry proteomics to better understand cardiac disease. To image the very large proteins of human heart tissue, Ge combines fourier-transform ion cyclotron resonance (FT–ICR) mass spectrometry with electron-capture dissociation.[4] She has worked to create a top-down disease proteomic platform that allows for the separation, detection and characterisation of the biomarkers of heart damage.

Nanoproteomics, a technique developed by Ge and co-workers, makes use of nanoparticles and high resolution mass spectrometry to capture and characterise cardiac troponins, including troponin I.[5] [6] Being able to test for and characterise troponin I would help with the early detection and diagnosis of heart disease.[7] The peptide-functionalised superparamagnetic nanoparticles are combined with top-down mass spectrometry to identify the molecular fingerprints of troponins. Rather than just detecting cardiac troponins, which is possible using ELISA-based antibody testing, this higher level of characterisation will allow Ge to identify various forms of modified troponins, allowing a personalised understanding of cardiac disease.

Ge served on the board of the Top-Down Proteomics Consortium,[8] on the editorial board of the Journal of Muscle Research and Cell Motility,[9] as treasurer for the American Society for Mass Spectrometry (2016-2018).[10]

Ying Ge publications indexed by Google Scholar.

Awards and honours

Selected publications

Notes and References

  1. Web site: yge Department of Chemistry. 2020-10-18. www2.chem.wisc.edu. en.
  2. Top down characterization of proteins by electron capture dissociation and blackbody infrared radiative dissociation mass spectrometry. 2002. English. Ying. Ge. 52791635.
  3. Web site: Ying Ge. 2021-10-31. HUPO Connect 2020. en-US.
  4. Web site: Biemann Medal. 2020-10-18. www.asms.org.
  5. Web site: 2020-08-07. New Nanoparticle Technology Reveals Common Marker of Heart Disease. 2020-10-19. AZoNano.com. en.
  6. Web site: Nanoparticle system captures heart-disease biomarker from blood for in-depth analysis. 2020-10-19. phys.org. en.
  7. Web site: 2020-08-07. Biomarker for Heart Disease Captured by Novel Nanoparticle Technology. 2020-10-19. GEN - Genetic Engineering and Biotechnology News. en-US.
  8. Web site: Board of Directors – Consortium for Top-Down Proteomics. 2021-10-31. en-US.
  9. Web site: Journal of Muscle Research and Cell Motility. 2021-10-31. Springer. en.
  10. Brodbelt. Jenny. Li. Lingjun. 2021-08-23. Editorial: Focus on Top-Down Proteomics: Technology Advances and Biomedical Applications, Honoring Dr. Ying Ge, Recipient of the 2020 ASMS Biemann Medal. Journal of the American Society for Mass Spectrometry. 33 . 9 . 1586–1589 . 10.1021/jasms.1c00209. 34423982 . 237268712 . 1044-0305. free.
  11. Web site: Ying Ge Receives Georges Guiochon Faculty Fellowship at HPLC 2016. 2020-10-18. Chromatography Online. 22 June 2016 .
  12. Web site: 2018-03-15. Dr. Ying Ge awarded H.I. Romnes Faculty Fellowship. 2020-10-18. Molecular and Cellular Pharmacology Training Program. en-US.
  13. Web site: The Power List 2019 . 2022-12-27 . The Analytical Scientist . en.
  14. Web site: Ying Ge. 2020-10-18. The Analytical Scientist. en.
  15. Web site: HUPO - 2021 HUPO Awards. 2021-10-31. hupo.org.
  16. Web site: The Power List 2021 . 2022-12-27 . The Analytical Scientist . en.