Yi Tang (biochemist) explained

Yi Tang is a biochemist and professor in the Department of Chemistry and Biochemistry and the Department of Chemical and Biomolecular Engineering at the University of California, Los Angeles.[1] [2] His research interests include the discovery, functional characterization, and engineering of natural product biosynthetic enzymes.[3] He was awarded the 2014 Eli Lilly Award in Biological Chemistry.[4]

Education

Tang attended college at Pennsylvania State University and earned his PhD in Chemistry in 2002 from the California Institute of Technology, where he worked in the lab of Professor David Tirrell.[5]

Career and research

From 2002 to 2004, Tang pursued postdoctoral studies at the Stanford University in the lab of Professor Chaitan Khosla. In 2004, Tang joined the faculty of the Department of Chemical and Biomolecular Engineering the University of California, Los Angeles. His group's research has focused on studying the biosynthesis of natural products from Streptomyces and filamentous fungi as well as engineering enzymes that can be used for the production of pharmaceutical compounds. One demonstration of the latter approach has been his group's development of a biocatalytic approach for making the commonly prescribed lipid-lowering medication simvastatin.[6] [7]

Web of Science lists 254 publications authored by Tang in peer-reviewed scientific journals that have been cited over 10,000 times, leading to an h-index of 58.[8] His lab's three most cited papers have been cited >180 times each.[9] [10] [11]

Awards and honors

Notes and References

  1. Web site: Yi Tang Lab@UCLA - Members . 2023-01-07 . sites.google.com . en-US.
  2. Web site: Tang, Yi . 2023-01-07 . The David and Lucile Packard Foundation . en-US.
  3. Web site: Yi Tang . 2023-01-07 . scholar.google.com.
  4. Web site: ACS Division of Biological Chemistry . 7 January 2023 . Previous Eli Lilly Award in Biological Chemistry Recipients .
  5. Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA . Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability . Angewandte Chemie . 40 . 8 . 1494–1496 . April 2001 . 29712367 . 10.1002/1521-3773(20010417)40:8<1494::AID-ANIE1494>3.0.CO;2-X .
  6. Web site: Structural secrets of enzyme used to make popular anti-cholesterol drug revealed . 2023-01-07 . ScienceDaily . en.
  7. Web site: US EPA . OCSPP . 2013-02-26 . Presidential Green Chemistry Challenge: 2012 Greener Synthetic Pathways Award . 2023-01-07 . www.epa.gov . en.
  8. Web site: Web of Science . 2023-01-07 . www.webofscience.com.
  9. Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO . 6 . Minimum Information about a Biosynthetic Gene cluster . Nature Chemical Biology . 11 . 9 . 625–631 . September 2015 . 26284661 . 5714517 . 10.1038/nchembio.1890 .
  10. Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, Dorrestein PC, Vederas JC, Tang Y . 6 . Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis . Journal of the American Chemical Society . 132 . 13 . 4530–4531 . April 2010 . 20222707 . 2861853 . 10.1021/ja100060k .
  11. Ma SM, Li JW, Choi JW, Zhou H, Lee KK, Moorthie VA, Xie X, Kealey JT, Da Silva NA, Vederas JC, Tang Y . 6 . Complete reconstitution of a highly reducing iterative polyketide synthase . Science . 326 . 5952 . 589–592 . October 2009 . 19900898 . 2875069 . 10.1126/science.1175602 .

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