YchF-GTPase C terminal protein domain explained

Symbol:	YchF-GTPase_C
C terminal domain of YchF-GTPase
Pfam:	PF06071
Pfam Clan:	CL0072
Interpro:	IPR013029
Scop:	1ni3
Cdd:	cd04867

In molecular biology, this protein domain is found at the C terminus of the GTP-binding protein, YchF-GTPase found in both prokaryotes and eukaryotes.

Function

The function of this protein domain remains unknown, however, it is putatively thought to be necessary for ribosome function or for signal transduction from the ribosome to downstream targets. Additionally, GTPases are often described as a molecular switch.^[1]

Structure

The crystal structure of Haemophilus influenzae has been determined.^[2] This protein consists of three domains, of which the C-terminal domain which is composed of a six-stranded half-barrel curved around an alpha helix.

Notes and References

1. Caldon CE, Yoong P, March PE . Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function. . Mol Microbiol . 2001 . 41 . 2 . 289–97 . 11489118 . 10.1046/j.1365-2958.2001.02536.x. free .
2. Teplyakov A, Obmolova G, Chu SY, Toedt J, Eisenstein E, Howard AJ, Gilliland GL . Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid . J. Bacteriol. . 185 . 14 . 4031–7 . July 2003 . 12837776 . 164861 . 10.1128/jb.185.14.4031-4037.2003.