| Official Name: | Yakshino |
| Native Name: | Якшино |
| Settlement Type: | Village |
| Pushpin Map: | Russia Vologda Oblast#Russia |
| Subdivision Type: | Country |
| Subdivision Name: | Russia |
| Subdivision Name1: | Vologda Oblast |
| Subdivision Name3: | Vytegorsky District |
| Subdivision Type4: | Municipality |
| Utc Offset1: | +3:00 |
| Coordinates: | 60.8167°N 58°W[1] |
Yakshino (Russian: Якшино) is a rural locality (a village) in Saminskoye Rural Settlement, Vytegorsky District, Vologda Oblast, Russia. The population was 24 as of 2002.[2] There are 2 streets.[3]
Yakshino is located 63 km southeast of Vytegra (the district's administrative centre) by road. Ryumino is the nearest rural locality.[4]