YTHDF2 explained

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene.^[1]

Function

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline-rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. Also, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively, spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012].

See also

N⁶-Methyladenosine

Further reading

• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ . Antigens recognized by autologous antibody in patients with renal-cell carcinoma . Int. J. Cancer . 83 . 4 . 456–64 . 1999 . 10508479 . 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. free .
• Cardelli M, Marchegiani F, Cavallone L, Olivieri F, Giovagnetti S, Mugianesi E, Moresi R, Lisa R, Franceschi C . A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity . J. Gerontol. A Biol. Sci. Med. Sci. . 61 . 6 . 547–56 . 2006 . 16799135 . 10.1093/gerona/61.6.547. free .
• Cardelli M, Marchegiani F, Cavallone L, Olivieri F, Giovagnetti S, Mugianesi E, Moresi R, Lisa R, Franceschi C . A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity . J. Gerontol. A Biol. Sci. Med. Sci. . 61 . 6 . 547–56 . 2006 . 16799135 . 10.1093/gerona/61.6.547. free .
• Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C . N6-methyladenosine-dependent regulation of messenger RNA stability . Nature . 505 . 7481 . 117–20 . 2014 . 24284625 . 3877715 . 10.1038/nature12730 . 2014Natur.505..117W .
• Li F, Zhao D, Wu J, Shi Y . Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition . Cell Res. . 24 . 12 . 1490–2 . 2014 . 25412658 . 4260351 . 10.1038/cr.2014.153 .
• Zhu T, Roundtree IA, Wang P, Wang X, Wang L, Sun C, Tian Y, Li J, He C, Xu Y . Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine . Cell Res. . 24 . 12 . 1493–6 . 2014 . 25412661 . 4260350 . 10.1038/cr.2014.152 .
• Xu C, Liu K, Ahmed H, Loppnau P, Schapira M, Min J . Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins . J. Biol. Chem. . 290 . 41 . 24902–13 . 2015 . 26318451 . 4598999 . 10.1074/jbc.M115.680389 . free .
• Tirumuru N, Zhao BS, Lu W, Lu Z, He C, Wu L . N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression . eLife . 5 . 2016 . 27371828 . 4961459 . 10.7554/eLife.15528 . free .

Notes and References

1. Web site: Entrez Gene: YTH N6-methyladenosine RNA binding protein 2. 2017-12-24.