YEATS domain explained

Symbol:	YEATS
YEATS domain
Width:	350
Pfam:	PF03366
Interpro:	IPR005033
Prosite:	PS51037
Pdb:	,,,,

In molecular biology, the YEATS domain is a protein domain found in a variety of proteins from eukaryotic organisms.^[1] YEATS domain proteins are found in a variety of chromatin modification molecular complexes. Structurally the domain has an immunoglobulin like fold.^[2] The YEATS domain has shown to bind to acetyllysine protein modifications.^[3] In addition to lysine acetylation, the YEATS domain has shown to be a reader domain for various lysine acylations, with highest affinity for lysine crotonylation.^{[4] [5]}

See also

Bromodomain

Notes and References

1. Schulze JM, Wang AY, Kobor MS . YEATS domain proteins: a diverse family with many links to chromatin modification and transcription . Biochem. Cell Biol. . 87 . 1 . 65–75 . 2009 . 19234524 . 10.1139/O08-111 .
2. Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS . Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation . Proc. Natl. Acad. Sci. U.S.A. . 106 . 51 . 21573–8 . 2009 . 19966225 . 2799888 . 10.1073/pnas.0906539106 . free .
3. Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SY, Li W, Li H, Shi X . AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation . Cell . 159 . 3 . 558–71 . 2014 . 25417107 . 4344132 . 10.1016/j.cell.2014.09.049 .
4. Li Y, Sabari BR, Panchenko T, Wen H, Zhao D, Guan H, Wan L, Huang H, Tang Z, Zhao Y, Roeder RG, Shi X, Allis CD, Li H . Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. Molecular Cell . 62 . 2 . 181–193 . 2016 . 27105114 . 10.1016/j.molcel.2016.03.028 . 4841940 .
5. Andrews FH, Shinsky SA, Shanle EK, Bridgers JB, Gest A, Tsun IK, Krajewski K, Shi X, Strahl BD, Kutateladze TG . The Taf14 YEATS domain is a reader of histone crotonylation . Nat. Chem. Biol. . 12 . 6 . 396–8 . 2016 . 27089029 . 10.1038/nchembio.2065 . 4871749 .