YAF2 explained

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.^{[1] [2]}

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.

Further reading

• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Mädge B, Geisen C, Möröy T, Schwab M . Yaf2 inhibits Myc biological function . Cancer Lett. . 193 . 2 . 171–6 . 2003 . 12706874 . 10.1016/S0304-3835(02)00696-1 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ogawa H . A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells . Science . 296 . 5570 . 1132–6 . 2002 . 12004135 . 10.1126/science.1069861 . Ishiguro K . Gaubatz S . 3 . Livingston . DM . Nakatani . Y . 2002Sci...296.1132O . 34863978 .
• Sawa C . YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors . J. Biol. Chem. . 277 . 25 . 22484–90 . 2002 . 11953439 . 10.1074/jbc.M203060200 . Yoshikawa T . Matsuda-Suzuki F . 3 . Deléhouzée . S . Goto . M . Watanabe . H . Sawada . J . Kataoka . K . Handa . H . free .
• Bannasch D, Mädge B, Schwab M . Functional interaction of Yaf2 with the central region of MycN . Oncogene . 20 . 41 . 5913–9 . 2001 . 11593398 . 10.1038/sj.onc.1204747 . 33486505 .

Notes and References

1. Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC . Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1 . Nucleic Acids Res . 25 . 4 . 843–9 . Mar 1997 . 9016636 . 146511 . 10.1093/nar/25.4.843 .
2. Web site: Entrez Gene: YAF2 YY1 associated factor 2.