XPOT explained

Exportin-T is a protein that in humans is encoded by the XPOT gene.^{[1] [2] [3]}

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.

Further reading

• Arts GJ, Kuersten S, Romby P, etal . The role of exportin-t in selective nuclear export of mature tRNAs. . EMBO J. . 17 . 24 . 7430–41 . 1999 . 9857198 . 10.1093/emboj/17.24.7430 . 1171087 .
• Kruse C, Willkomm DK, Grünweller A, etal . Export and transport of tRNA are coupled to a multi-protein complex. . Biochem. J. . 346 . 1. 107–15 . 2000 . 10657246 . 10.1042/0264-6021:3460107 . 1220829 .
• Kutay U, Hartmann E, Treichel N, etal . Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. . J. Biol. Chem. . 275 . 51 . 40163–8 . 2001 . 11024021 . 10.1074/jbc.M006242200 . free . 11858/00-001M-0000-0015-3D4E-B . free .
• Kuersten S, Arts GJ, Walther TC, etal . Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. . Mol. Cell. Biol. . 22 . 16 . 5708–20 . 2002 . 12138183 . 10.1128/MCB.22.16.5708-5720.2002 . 133969 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Suzuki T, Koyama Y, Hayakawa S, etal . 1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells. . Biomed. Res. . 27 . 2 . 89–92 . 2006 . 16707848 . 10.2220/biomedres.27.89 . free .
• Li S, Sprinzl M . Interaction of immobilized human exportin-t with calf liver tRNA. . RNA Biol . 3 . 4 . 145–9 . 2007 . 17224653 . 10.4161/rna.3.4.3679. free .

Notes and References

1. Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D . Identification of a tRNA-specific nuclear export receptor . Mol Cell . 1 . 3 . 359–69 . Jul 1998 . 9660920 . 10.1016/S1097-2765(00)80036-2 . free .
2. Arts GJ, Fornerod M, Mattaj IW . Identification of a nuclear export receptor for tRNA . Curr Biol . 8 . 6 . 305–14 . May 1998 . 9512417 . 10.1016/S0960-9822(98)70130-7 . 17803674 . free .
3. Web site: Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs).