| Xié River | |
| Pushpin Map: | Brazil |
| Pushpin Map Caption: | Mouth location in Brazil |
| River System: | Rio Negro |
| Source1 Location: | São Gabriel da Cachoeira, Amazonas, Brazil |
| Source1 Coordinates: | 1.348°N -67.5406°W |
| Mouth Coordinates: | 0.9229°N -67.2011°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Xié River (pt|Rio Xié) is a river of Amazonas state in north-western Brazil. It is a right tributary of the Rio Negro.
The river flows through the 7999000ha Alto Rio Negro Indigenous Territory, created in 1998.The majority of the population of the Xié River are Baré and Werekena people.