Xiaoliang Sunney Xie Explained
Xiaoliang Sunney Xie (; born 24 June 1962) is a Chinese biophysicist well known for his contributions to the fields of single-molecule biophysical chemistry, coherent Raman Imaging and single-molecule genomics. In 2023, Xie renounced his U.S. citizenship in order to reclaim his Chinese citizenship.[2]
Early life
Xie was born in Beijing in 1962 with ancestral roots in Hepu County, Guangxi. He received his B.Sc. in chemistry from Peking University in 1984, and his Ph.D. in physical chemistry in 1990 from University of California at San Diego. After a brief postdoctoral appointment at University of Chicago, he joined Pacific Northwest National Laboratory, where he rose from senior research scientist to chief scientist. In 1998, he became the first tenured professor recruited by Harvard University among Chinese scholars who came to the United States since Chinese economic reform.
Research
He had been the Mallinckrodt Professor of Chemistry and Chemical Biology at Harvard University until 2018, when he became the Lee Shau-kee Professor of Peking University. He was the Director of Biomedical Pioneering Innovation Center (BIOPIC) in 2010-2021, and the Director of Beijing Advanced Innovation Center for Genomics (ICG) in 2016-2021, both at Peking University.
As a pioneer of single-molecule biophysical chemistry, Coherent Raman scattering microscopy, and single-cell genomics, he made major contributions to the emergence of these fields. Furthermore, he has made significant advances on medical applications of label-free optical imaging and single-cell genomics. In particular, his inventions in single-cell genomics have been used in in vitro fertilization benefited thousands of families by avoiding the transmission of monogenic diseases to their newborns.
More than fifty of his students and post-doctorates have become professors at major universities around the world, and two are co-founders of start-up companies.Professor Xie’s current research interests include the following scientific, technological, and medical areas:
- Scientific: Single-molecule enzymology, Single-molecule biophysical chemistry, Gene expression and regulation, Epigenetics, Mechanism of cell differentiation and reprogramming, Chromosome structure and dynamics, and Genomic instability;
- Technological: Single-molecule imaging, Single-cell genomics, Coherent Raman scattering microscopy, DNA sequencing;
- Medical: Preimplantation genetic testing in in vitro fertilization, COVID19 vaccine and neutralizing antibody drugs for SARS-CoV-2 variants and Early cancer diagnosis.
Honors and awards
Selected Literature
COVID-19 Research
- Du . Shuo . Liu . Pulan . Zhang . Zhiying . Xiao . Tianhe . Yasimayi . Ayijiang . Huang . Weijin . Wang . Youchun . Cao . Yunlong . Xie . Xiaoliang Sunney . Xiao . Junyu . Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants . Cell Research . Springer Science and Business Media LLC . 31 . 10 . 25 August 2021 . 1001-0602 . 10.1038/s41422-021-00555-0 . 1130–1133. 34433900 . 8385480 .
- Cao . Yunlong . Wang . Jing . Jian . Fanchong . Xiao . Tianhe . Song . Weiliang . Yisimayi . Ayijiang . Huang . Weijin . Li . Qianqian . Wang . Peng . An . Ran . Wang . Jing . Wang . Yao . Niu . Xiao . Yang . Sijie . Liang . Hui . Sun . Haiyan . Li . Tao . Yu . Yuanling . Cui . Qianqian . Liu . Shuo . Yang . Xiaodong . Du . Shuo . Zhang . Zhiying . Hao . Xiaohua . Shao . Fei . Jin . Ronghua . Wang . Xiangxi . Xiao . Junyu . Wang . Youchun . Xie . Xiaoliang Sunney . Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies . Nature . Springer Science and Business Media LLC . 602 . 7898 . 23 December 2021 . 0028-0836 . 10.1038/s41586-021-04385-3 . 657–663. 35016194 . 8866119 .
- Cao . Yunlong . Yisimayi . Ayijiang . Bai . Yali . Huang . Weijin . Li . Xiaofeng . Zhang . Zhiying . Yuan . Tianjiao . An . Ran . Wang . Jing . Xiao . Tianhe . Du . Shuo . Ma . Wenping . Song . Liyang . Li . Yongzheng . Li . Xiang . Song . Weiliang . Wu . Jiajing . Liu . Shuo . Li . Xuemei . Zhang . Yonghong . Su . Bin . Guo . Xianghua . Wei . Yangyang . Gao . Chuanping . Zhang . Nana . Zhang . Yifei . Dou . Yang . Xu . Xiaoyu . Shi . Rui . Lu . Bai . Jin . Ronghua . Ma . Yingmin . Qin . Chengfeng . Wang . Youchun . Feng . Yingmei . Xiao . Junyu . Xie . Xiaoliang Sunney . Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines . Cell Research . Springer Science and Business Media LLC . 31 . 7 . 21 May 2021 . 1001-0602 . 10.1038/s41422-021-00514-9 . 732–741. 34021265 . 8138844 .
- Du . Shuo . Cao . Yunlong . Zhu . Qinyu . Yu . Pin . Qi . Feifei . Wang . Guopeng . Du . Xiaoxia . Bao . Linlin . Deng . Wei . Zhu . Hua . Liu . Jiangning . Nie . Jianhui . Zheng . Yinghui . Liang . Haoyu . Liu . Ruixue . Gong . Shuran . Xu . Hua . Yisimayi . Ayijiang . Lv . Qi . Wang . Bo . He . Runsheng . Han . Yunlin . Zhao . Wenjie . Bai . Yali . Qu . Yajin . Gao . Xiang . Ji . Chenggong . Wang . Qisheng . Gao . Ning . Huang . Weijin . Wang . Youchun . Xie . X. Sunney . Su . Xiao-dong . Xiao . Junyu . Qin . Chuan . Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy . Cell . Elsevier BV . 183 . 4 . 2020 . 0092-8674 . 10.1016/j.cell.2020.09.035 . 1013–1023.e13. 32970990 . 7489885 .
- Cao . Yunlong . Su . Bin . Guo . Xianghua . Sun . Wenjie . Deng . Yongqiang . Bao . Linlin . Zhu . Qinyu . Zhang . Xu . Zheng . Yinghui . Geng . Chenyang . Chai . Xiaoran . He . Runsheng . Li . Xiaofeng . Lv . Qi . Zhu . Hua . Deng . Wei . Xu . Yanfeng . Wang . Yanjun . Qiao . Luxin . Tan . Yafang . Song . Liyang . Wang . Guopeng . Du . Xiaoxia . Gao . Ning . Liu . Jiangning . Xiao . Junyu . Su . Xiao-dong . Du . Zongmin . Feng . Yingmei . Qin . Chuan . Qin . Chengfeng . Jin . Ronghua . Xie . X. Sunney . Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells . Cell . Elsevier BV . 182 . 1 . 2020 . 0092-8674 . 10.1016/j.cell.2020.05.025 . 73–84.e16. 32425270 . 7231725 .
Single-Cell Genomics
- Tan . Longzhi . Xie . X. Sunney . 2018. A Near-complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium . Chem Senses . 43 . 6. 427–432 . 10.1093/chemse/bjy030 . 29796642 . 6454507 .
- Xu . Juanjuan . Fang . Rui . Chen . Li . Chen . Daozhen . Xiao . Jian-Ping . Yang . Weimin . Wang . Honghua . Song . Xiaoqing . Ma . Ting . Bo . Shiping . Shi . Chong . Ren . Jun . Huang . Lei . Cai . Li-Yi . Yao . Bing . Xie . X Sunney . Lu . Sijia . 2016 . Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization . Proc Natl Acad Sci USA . 113 . 42. 11907–1 . 10.1073/pnas.1613294113 . 27688762 . 5081593 . 2016PNAS..11311907X . free .
- Chen . Chongyi . Xing . Dong . Tan . Longzhi . Li . Heng . Zhou . Guangyu . Huang . Lei . Xie . X. Sunney . 2017 . Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI) . Science . 356 . 6334. 189–194 . 10.1126/science.aak9787. 2017Sci...356..189C . 5538131 . 28408603.
- Yan . Liying . Huang . Lei . Xu . Liya . Huang . Jin . Ma . Fei . Zhu . Xiaohui . Tang . Yaqiong . Liu . Mingshan . Lian . Ying . Liu . Ping . Li . Rong . Lu . Sijia . Tang . Fuchou . Qiao . Jie . Xie . X Sunney . 2015 . Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses . Proc Natl Acad Sci USA . 112 . 52. 15964–15969 . 10.1073/pnas.1523297113. 2015PNAS..11215964Y . 4702982 . 26712022. free .
- Hou . Yu . Fan . Wei . Yan . Liying . Li . Rong . Lian . Ying . Huang . Jin . Li . Jinsen . Xu . Liya . Tang . Fuchou . Xie . X. Sunney . Qiao . Jie . 2013 . Genome Analyses of Single Human Oocytes . Cell . 155 . 7. 1492–1506 . 10.1016/j.cell.2013.11.040. 24360273 . free .
- Zong . Chenghang . Lu . Sijia . Chapman . Alec R. . Xie . X. Sunney . 2012 . Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell . Science . 338 . 6114. 1622–1626 . 10.1126/science.1229164. 2012Sci...338.1622Z . 3600412 . 23258894.
Gene Expression and Regulation
- Chong . Shasha . Chen . Chongyi . Ge . Hao . Sunney . Xie X. . 2014 . Mechanism of Transcriptional Bursting in Bacteria . Cell . 158 . 2. 314–326 . 10.1016/j.cell.2014.05.038 . 25036631 . 4105854.
- Taniguchi . Yuichi . Choi . Paul J. . Li . Gene-Wei . Chen . Huiyi . Babu . Mohan . Hearn . Jeremy . Emili . Andrew . Xie . X. Sunney . 2010 . Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells . Science . 329 . 5991. 533–538 . 10.1126/science.1188308. 2922915 . 2010Sci...329..533T . 20671182.
- Choi . Paul J. . Cai . Long . Frieda . Kirsten . Xie . X. Sunney . 2008 . A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell . Science . 322 . 5900. 442–446 . 10.1126/science.1161427. 2008Sci...322..442C . 2819113 . 18927393.
- Elf . Johan . Li . Gene-Wei . Xie . X. Sunney . 2007 . Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell . Science . 316 . 5828. 1191–1194 . 10.1126/science.1141967. 2853898 . 2007Sci...316.1191E . 17525339.
- Yu . Ji . Xiao . Jie . Ren . Xiaojia . Lao . Kaiqin . Xie . X. Sunney . 2006 . Probing Gene Expression in Live Cells, One Protein Molecule at a Time . Science . 311 . 5767. 1600–1603 . 10.1126/science.1119623. 16543458 . 2006Sci...311.1600Y . 14506807 .
- Cai . Long . Friedman . Nir . Xie . X. Sunney . 2006 . Stochastic Protein Expression in Individual Cells at the Single Molecule Level . Nature . 440 . 7082. 358–362 . 10.1038/nature04599. 16541077 . 2006Natur.440..358C . 4426109 .
Single Molecule Enzymology
- Chong . Shasha . Chen . Chongyi . Ge . Hao . Sunney . Xie X. . 2014 . Mechanism of Transcriptional Bursting in Bacteria . Cell . 158 . 2. 314–326 . 10.1016/j.cell.2014.05.038 . 25036631 . 4105854.
- Kim . Sangjin . Broströmer . Erik . Xing . Dong . Jin . Jianshi . Chong . Shasha . Ge . Hao . Wang . Siyuan . Gu . Chan . Yang . Lijiang . Gao . Yiqin . Su . Xiao-dong . Sun . Yujie . Xie . X. Sunney . 2013 . Probing Allostery Through DNA . Science . 339 . 6121. 816–819 . 10.1126/science.1229223. 2013Sci...339..816K . 3586787 . 23413354.
- English . Brian P. . Min . Wei . van Oijen . Antoine M. . Lee . Kang Taek . Luo . Guobin . Sun . Hongye . Cherayil . Binny J. . Kou . S.C. . Xie . X. Sunney . 2006 . Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited . Nat Chem Biol . 2 . 2. 87–94 . 10.1038/nchembio759 . 16415859 . 2201882 .
- Yang . Haw . Luo . Guobin . Karnchanaphanurach . Pallop . Louie . Tai-Man . Rech . Ivan . Cova . Sergio . Xun . Luying . Xie . X. Sunney . 2003 . Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer . Science . 302 . 5643. 262–266 . 10.1126/science.1086911. 2003Sci...302..262Y . 14551431. 18706150 .
- Lu . H. Peter . Xun . Luying . Xie . X. Sunney . 1998 . Single-Molecule Enzymatic Dynamics . Science . 282 . 5395. 1877–1882 . 10.1126/science.282.5395.1877 . 9836635. 1998Sci...282.1877P .
Coherent Raman Imaging
- Ji . Minbiao . Orringer . Daniel A. . Freudiger . Christian W. . Ramkissoon . Shakti . Liu . Xiaohui . Lau . Darryl . Golby . Alexandra J. . Norton . Isaiah . Hayashi . Marika . Agar . Nathalie Y. R. . Young . Geoffrey S. . Spino . Cathie . Santagata . Sandro . Camelo-Piragua . Sandra . Ligon . Keith L. . Sagher . Oren . Xie . X. Sunney . 2013 . Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy . Science Translational Medicine . 5 . 201. 201 . 10.1126/scitranslmed.3005954. 3806096 . 24005159 .
- Wang . Meng C. . Min . Wei . Freudiger . Christian W. . Ruvkun . Gary . Xie . X. Sunney . 2011 . RNAi Screening for Fat Regulatory Genes with SRS Microscopy . Nat Methods . 8 . 2. 135–138 . 10.1038/nmeth.1556. 3061290 . 21240281.
- Saar . Brian G. . Freudiger . Christian W. . Reichman . Jay . Stanley . C. Michael . Holtom . Gary R. . Xie . X. Sunney . 2010 . Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering . Science . 330 . 6009. 1368–1370 . 10.1126/science.1197236. 2010Sci...330.1368S . 3462359 . 21127249 .
- Freudiger . Christian W. . Min . Wei . Saar . Brian G. . Lu . Sijia . Holtom . Gary R. . He . Chengwei . Tsai . Jason C. . Kang . Jing X. . Xie . X. Sunney . 2008 . Label-Free Biomedical Imaging with High sensitivity by Stimulated Raman Scattering Microscopy . Science . 322 . 5909. 1857–1860 . 10.1126/science.1165758. 2008Sci...322.1857F . 19095943 . 3576036.
- Evans . Conor L. . Potma . Eric O. . Puoris'Haag . Mehron . Côté . Daniel . Lin . Charles P. . Xie . X. Sunney . 2005 . Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy . Proc. Natl. Acad. Sci. . 102 . 46. 16807–16812 . 10.1073/pnas.0508282102. 2005PNAS..10216807E . 1283840 . 16263923. free .
- Zumbusch . Andreas . Holtom . Gary R. . Xie . X. Sunney . 1999 . Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering . Phys Rev Lett . 82 . 20. 4142–4145 . 10.1103/physrevlett.82.4142 . 1999PhRvL..82.4142Z.
Single Molecule Imaging
- Zhou . Yuexin . Wang . Ping . Tian . Feng . Gao . Ge . Huang . Lei . Wei . Wensheng . Xie . X. Sunney . 2017. Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging . Cell Res . 27. 2. 298–301. 10.1038/cr.2017.9 . 28084328 . 5339855 . free .
- Chong . Shasha . Min . Wei . Xie . X. Sunney . 2010 . Ground-State Depletion Microscopy:Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature . J Phys Chem Lett . 1 . 23. 3316–3322 . 10.1021/jz1014289. 1244482 .
- Min . Wei . Lu . Sijia . Chong . Shasha . Roy . Rahul . Holtom . Gary R. . Xie . X. Sunney . 2009 . Imaging Chromophores with Undetectable Fluorescence by Stimulated Emission Microscopy . Nature . 461 . 7267. 1105–1109 . 10.1038/nature08438. 19847261 . 2009Natur.461.1105M . 1460208 .
- Sánchez . Erik J. . Novotny . Lukas . Xie . X. Sunney . 1999 . Near-field Fluorescence Microscopy Based on Two-photon Excitation with Metal Tips . Phys Rev Lett . 82 . 20. 4014–4017 . 10.1103/physrevlett.82.4014 . 1999PhRvL..82.4014S.
- Sánchez . Erik J. . Novotny . Lukas . Holtom . G.R. . Xie . X. Sunney . 1997 . Room-Temperature Fluorescence Imaging and Spectroscopy of Single Molecules by Two-Photon Excitation . J Phys Chem A . 101 . 38. 7019–7023 . 10.1021/jp971915b. 1997JPCA..101.7019S .
- Xie . X. Sunney . Dunn . Robert C. . 1994 . Probing Single Molecule Dynamics . Science . 265 . 5170. 361–364 . 10.1126/science.265.5170.361. 17838036 . 1994Sci...265..361X . 6161198 .
See also
External links
Notes and References
- Web site: About Professor Xie . 2018-10-10 . 2018-10-10 . https://web.archive.org/web/20181010135101/https://bernstein.harvard.edu/pages/AboutProfXie.html . dead .
- Web site: Xie Xiaoliang is latest Chinese scientist to give up US citizenship. 9 June 2023 . South China Morning Post. 20 June 2023.
- Web site: PKU Professor Xiaoliang Sunney Xie awarded Qiu Shi Outstanding Scientist Award of 2017 . . 2018-10-10 . 2018-10-10 . https://web.archive.org/web/20181010135316/http://newsen.pku.edu.cn/news_events/news/focus/6288.htm . live .
- Web site: 关于公布2017年中国科学院院士增选当选院士名单的公告. 2017-11-28. Chinese Academy of Sciences. zh. 2019-11-22. 2019-11-23. https://web.archive.org/web/20191123004136/http://www.cas.cn/tt/201711/t20171128_4624789.shtml. live.
- Web site: National Academy of Medicine Elects 79 New Members . 2016-11-02 . 2019-10-18 . https://web.archive.org/web/20191018212511/https://nam.edu/national-academy-of-medicine-elects-79-new-members/ . live .
- Web site: Albany Medical Center Prize . 2015-04-20 . 2015-04-23 . https://web.archive.org/web/20150423132816/http://www.amc.edu/Academic/AlbanyPrize/Recipients/recipients_current/xie.cfm . live .
- Web site: Peter Debye Award . 2015-04-20 . 2017-08-25 . https://web.archive.org/web/20170825103657/https://www.acs.org/content/acs/en/funding-and-awards/awards/national/bytopic/peter-debye-award-in-physical-chemistry.html . live .
- Web site: NIH Director's Pioneer Award 2013 . 2013-11-14 . 2014-02-21 . https://web.archive.org/web/20140221222623/http://commonfund.nih.gov/pioneer/Recipients13 . live .
- Web site: Ellis R. Lippincott Award . 2016-11-02 . 2016-10-31 . https://web.archive.org/web/20161031174327/http://www.osa.org/en-us/awards_and_grants/awards/award_description/ellislippincott/ . live .
- Web site: Berthold Leibinger Zukunftspreis . 2015-04-20 . 2016-10-27 . https://web.archive.org/web/20161027111546/http://www.leibinger-stiftung.de/de/foerderaktivitaeten/laser-forschungs-innovationspreis/zukunftspreis.html . live .
- Web site: Biography of Xie from the Website of the Willis E. Lamb Award (displayed June 4, 2008) . June 4, 2008 . August 20, 2008 . https://web.archive.org/web/20080820102559/http://www.lambmedal.org/2007/2007-xie.html . live .
- Web site: NIH Director's Pioneer Award 2004 . 2015-04-20 . 2016-12-20 . https://web.archive.org/web/20161220193407/http://commonfund.nih.gov/pioneer/Recipients04 . live .