Xiang-Jin Meng Explained

Xiang-Jin Meng, also known as X.J. Meng,^[1] is a Chinese-born American virologist. He is a university distinguished professor at Virginia Tech.^{[2] [3]} He studies emerging, re-emerging and zoonotic viruses of veterinary and human public health significance.^[4] He was elected a member of the National Academy of Sciences in 2016, a Fellow of the National Academy of Inventors in 2014, a Fellow of the American Academy of Microbiology in 2012, and a Fellow of the American Association for the Advancement of Science.^[5]

Xiang-Jin Meng
Birth Place:	Shandong Province, China
Alma Mater:	Binzhou Medical CollegeWuhan University College of Medicine (Hubei Medical College)Iowa State University, Ames, Iowa
Occupation:	University Distinguished Professor, Virginia Tech
Awards:	Fellow, American Association for the Advancement of Science (2022)Member, National Academy of Sciences (2016) Fellow, National Academy of Inventors (2014)Fellow, American Academy of Microbiology (2012)
Website:	http://www.vetmed.vt.edu/research/labs/meng/

Early life and education

Meng grew up in Gaomi, Shandong Province, China.^[6] He originally planned to pursue a career in chemical engineering, but instead he enrolled in Binzhou Medical College in 1980 as a medical student.

Receiving his medical degree in 1985, Meng studied at the Wuhan University College of Medicine (formerly Hubei Medical College) and earned a Master's degree in Microbiology and Immunology. There, he discovered his passion and curiosity for virology, under the supervision of his graduate advisor, Yu Sun, who was an experimental virologist and pathologist. Earning his Master's in 1988, Meng worked as a research fellow for three years at the Shandong Academy of Medical Sciences in Jinan.

In 1991, he was admitted to the interdepartmental Immunobiology graduate program at the Iowa State University. His PhD dissertation focused on an emerging virus, porcine reproductive and respiratory syndrome virus, in the laboratory of Prem S. Paul.^[7] After receiving his PhD in Immunobiology, he joined the Laboratory of Infectious Diseases as a John E. Fogarty Visiting Scientist and later as a Senior Staff Fellow in the labs of Suzanne U. Emerson and Robert H. Purcell at the National Institute of Allergy and Infectious Diseases at NIH in Bethesda, Maryland.

Career and research

Meng joined the faculty at Virginia Tech in 1999 as an Assistant Professor of Molecular Virology, and rose to the rank of full professor in 2007.^[8] He was named a university distinguished professor in 2013. In July 2020, Meng was appointed as the founding director of the Virginia Tech Center for Emerging, Zoonotic and Arthropod-borne Pathogens (CeZAP).^[9] From November 2021 to November 2022, Meng served as Interim Executive Director of the Fralin Life Sciences Institute at Virginia Tech.^[10]

His research mainly focuses on understanding the mechanism of virus replication and pathogenesis, defining the mechanisms of cross-species virus infection, and developing effective vaccines against emerging and zoonotic viruses. Meng's group discovered the swine hepatitis E virus from pigs and avian hepatitis E virus from chickens, which eventually lead to the recognition of human hepatitis E as a zoonotic disease. Meng's research also led to the invention of the first U.S. Department of Agriculture fully-license commercial vaccine, currently on the global market, against porcine circovirus type 2 (PCV2) and its associated diseases.^[11] Additionally, Meng works on a number of other important viruses including Hepatitis E virus, Porcine Reproductive and Respiratory Syndrome Virus, Torque Teno Sus Virus, and Porcine Epidemic Diarrhea Virus.^{[12] [13]}

Meng has authored and co-authored more than 359 peer-reviewed articles and book chapters, which have been cited for more than 36,183 times with a h-index of 99. He is ranked in the top 1% highly cited scientists in the field of microbiology (1997–2007) by Thomson Scientific's Essential Science Indicators.^[14] Meng is an inventor of more than 20 U.S. patent awards on viral vaccines and diagnostics.^[15]

Awards and honors

• 2023: Virginia Tech Life Time Achievement Award for Innovation^[16]
• 2022: Elected Fellow of the American Association for the Advancement of Science
• 2018: The Inaugural Lorraine J. Hoffman Graduate Alumni Award, Iowa State University, Ames, Iowa.^[17]
• 2017: State Council of Higher Education for Virginia (SCHEV) Outstanding Faculty Award.^{[18] [19]}
• 2016: Elected member of the National Academy of Sciences.^[20]
• 2014: Elected Fellow of the National Academy of Inventors.^[21]
• 2013: University Distinguished Professor title, a pre-eminent and life-time title bestowed by the university Board of Visitors.^[22]
• 2012: Elected Fellow of the American Academy of Microbiology.^[23]

Selected publications

• Meng, X.J.,P.S. Paul, and P.G. Halbur (1994). Molecular cloning and nucleotide sequencing of the 3' terminal genomic RNA of porcine reproductive and respiratory syndrome virus. Journal of General Virology 75:1795-1801. DOI: 10.1099/0022-1317-75-7-1795.
• Meng, X.J., R.H. Purcell, P.G. Halbur, J.R. Lehman, D.M. Webb, T.S. Tsareva, J.S. Haynes, B.J. Thacker, and S.U. Emerson (1997). A novel virus in swine is closely related to the human hepatitis E virus. Proceedings of the National Academy of Sciences USA 94:9860-9865. DOI: 10.1073/pnas.94.18.9860.
• Meng, X.J., P.G. Halbur, M. Shapiro, S. Govindarajan, J.D. Bruna, I. K. Mushahwar, R.H. Purcell, and S.U. Emerson (1998). Genetic and experimental evidence for cross-species infection by the swine hepatitis E virus. Journal of Virology. 72:9714-9721. DOI: 10.1128/JVI.72.12.9714-9721.1998.
• Fenaux M, T. Opriessnig, P.G. Halbur, F. Elvinger, and X.J. Meng (2004). A Chimeric Porcine Circovirus (PCV) with the Immunogenic Capsid Gene of the Pathogenic PCV2 Cloned Into the Genomic Backbone of the Non-Pathogenic PCV1 Induces Protective Immunity Against PCV2 Infection in Pigs. Journal of Virology. 78:6297-6303. DOI: 10.1128/JVI.78.12.6297-6303.2004.
• Billam P., F.F. Huang, Z.F. Sun, F.W. Pierson, R.B. Duncan, F. Elvinger, D.K. Guenette, T.E. Toth, and X. J. Meng (2005). Systematic pathogenesis and replication of avian hepatitis E virus in specific-pathogen-free adult chickens. Journal of Virology. 79(6):3429-37. DOI: 10.1128/JVI.79.6.3429-3437.2005.
• Huang YW, K.K. Harrall, B.A. Dryman, T. Opriessnig, E.M. Vaughn, M.B. Roof, and X.J. Meng. 2012. Serological profile of Torque teno sus virus species 1 (TTSuV1) in pigs and antigenic relationships between two TTSuV1 genotypes (1a and 1b), between two species (TTSuV1 and 2), and between porcine and human anelloviruses. Journal of Virology. 86(19):10628-10639. DOI: 10.1128/JVI.00176-12.
• Huang YW, A.W. Dickerman, P. Pineyro, L. Li, L. Fang, R. Kiehne, T. Opriessnig, and X.J. Meng. 2013. Origin, evolution, and genotyping of emergent porcine endemic diarrhea virus (PEDV) strains in the United States. mBio. 4(5):e00737-13. doi:10.1128/mBio.00737-13.
• Cao D, Cao QM, Subramaniam S, Yugo DM, Heffron CL, Rogers AJ, Kenney SP, Tian D, Matzinger SR, Overend C, Catanzaro N, LeRoith T, Wang H, Piñeyro P, Lindstrom N, Clark-Deener S, Yuan L, and X.J. Meng. 2017. Pig model mimicking chronic hepatitis E virus infection in immunocompromised patients to assess immune correlates during chronicity. Proceedings of the National Academy of Sciences USA. 114(27):6914-6923. DOI: 10.1073/pnas.1705446114.
• Sooryanrain H, C.L. Heffron, and X.J. Meng. 2020. The U-rich untranslated regions (UTR) of the hepatitis E virus induces differential type I and type III interferon responses in a host cell-dependent manner. mBio. 11:e03103-19. https://doi.org/10.1128/mBio.03103-19.

Notes and References

1. Web site: X.J. Meng - Google Scholar Citations. 2020-06-08. scholar.google.com.
2. Web site: Department of Biomedical Sciences and Pathobiology. 2020-06-08. Virginia Tech College of Veterinary Medicine (www.vetmed.vt.edu).
3. Web site: University Distinguished Professors. 2020-06-08. Virginia Tech Office of the President.
4. Web site: Xiang-Jin Meng. 2020-06-08. National Academy of Sciences (www.nasonline.org).
5. Web site: American Association for the Advancement of Science honors X.J. Meng as Lifetime Fellow . 2023-12-29 . news.vt.edu . en.
6. Viegas. Jennifer. 2017-07-03. Profile of Xiang-Jin Meng. Proceedings of the National Academy of Sciences. en. 114. 28. 7188–7190. 10.1073/pnas.1710342114. 28673980 . 5514775 . 0027-8424. free. 2017PNAS..114.7188V .
7. News: February 19, 2020. University Distinguished Professor of Molecular Virology X.J. Meng recognized by Iowa State University. Virginia Tech News.
8. News: Mar 12, 2008. Tech professor searches for hepatitis vaccine. Roanoke Times. 2020-06-08.
9. Web site: Center for Emerging, Zoonotic, and Arthropod-borne Pathogens to tackle infectious diseases . 2023-12-29 . news.vt.edu . en.
10. Web site: X.J. Meng named interim executive director of the Fralin Life Sciences Institute . 2023-12-29 . news.vt.edu . en.
11. News: 2006-07-18. Professor develops vaccine for pigs. USA Today. 2020-06-08.
12. Web site: Meng Laboratory. 2020-06-08. Virginia Tech College of Veterinary Medicine (www.vetmed.vt.edu).
13. Web site: TWiV 285: Hokies go viral. 2020-06-08. This Week in Virology Podcast. December 2015 .
14. Web site: X.J. Meng. 2020-06-08. ScienceWatch - Tracking Trends & Performance in Basic Research.
15. Web site: December 17, 2014. Veterinary college's X.J. Meng elected to the National Academy of Inventors. 2020-06-08. Virginia Tech.
16. Web site: Innovating around complex problems . 2023-12-29 . news.vt.edu . en.
17. News: February 19, 2020. Virginia Tech Daily. Virginia Tech News. 2020-06-08.
18. Web site: Virginia Tech's X.J. Meng earns SCHEV Outstanding Faculty Award. 2020-06-08. Virginia Tech News.
19. Web site: Dec 16, 2016. State Council of Higher Education for Virginia. 2020-06-08.
20. Web site: May 4, 2016. Virginia Tech's X.J. Meng elected to the National Academy of Sciences. 2020-06-08. Virginia Tech.
21. Web site: Dec 16, 2014. National Academy of Inventors Names 170 New Fellows. 2020-06-08. National Academy of Inventors.
22. Web site: June 4, 2013. Veterinary college's X.J. Meng honored as University Distinguished Professor. 2020-06-08. Virginia Tech.
23. Web site: March 20, 2012. X.J. Meng elected to the American Academy of Microbiology. 2020-06-08. Virginia Tech.