| Xapuri River | |
| Pushpin Map: | Brazil |
| River System: | Acre River |
| Source1 Location: | Acre state |
| Mouth Location: | Xapuri |
| Mouth Coordinates: | -10.6523°N -68.5094°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
Xapuri River is a river of Acre state in western Brazil. It forms small parts of the Brazil–Peru and Brazil–Bolivia international boundaries.
The river runs through the Chico Mendes Extractive Reserve, a sustainable use environmental unit created in 1990.It joins the Acre River at Xapuri.