XPNPEP1 explained
Xaa-Pro aminopeptidase 1 is an enzyme that in humans is encoded by the XPNPEP1 gene.[1]
Function
X-prolyl aminopeptidase (EC 3.4.11.9) is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate proline residue. Because of its specificity toward proline, it has been suggested that X-prolyl aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides, and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments, thereby complementing the pancreatic peptidases. Deficiency of X-prolyl aminopeptidase results in excretion of large amounts of imino-oligopeptides in urine (Blau et al., 1988).[supplied by OMIM]
Further reading
- Vanhoof G, De Meester I, Goossens F, Hendriks D, Scharpé S, Yaron A . Kininase activity in human platelets: cleavage of the Arg1-Pro2 bond of bradykinin by aminopeptidase P . Biochemical Pharmacology . 44 . 3 . 479–87 . Aug 1992 . 1510698 . 10.1016/0006-2952(92)90439-P .
- Blau N, Niederwieser A, Shmerling DH . Peptiduria presumably caused by aminopeptidase-P deficiency. A new inborn error of metabolism . Journal of Inherited Metabolic Disease . 11 . 240–2 . 1988 . Suppl 2 . 3141711 . 10.1007/BF01804246 . 32596444 .
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Vanhoof G, Goossens F, Juliano MA, Juliano L, Hendriks D, Schatteman K, Lin AH, Scharpé S . Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P) . Cytogenetics and Cell Genetics . 78 . 3–4 . 275–80 . 1998 . 9465902 . 10.1159/000134671 .
- Sprinkle TJ, Caldwell C, Ryan JW . . Archives of Biochemistry and Biophysics . 378 . 1 . 51–6 . Jun 2000 . 10871044 . 10.1006/abbi.2000.1792 .
- Cottrell GS, Hooper NM, Turner AJ . Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme . Biochemistry . 39 . 49 . 15121–8 . Dec 2000 . 11106490 . 10.1021/bi001585c .
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–9 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
Notes and References
- Web site: Entrez Gene: XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble.
