XJB-5-131 explained

Type:	Antioxidant -->
Legal Status:	experimental
Pubchem:	11693686
Chemspiderid:	9868412
Chebi:	173099
Smiles:	CC(C)CC(C=CC(Cc1ccccc1)C(=O)N2CCCC2C(=O)NC(C(C)C)C(=O)NC(CCCNC(=O)OCc3ccccc3)C(=O)NC4CC(N(C(C4)(C)C)[O])(C)C)NC(=O)OC(C)(C)C
Stdinchi:	1S/C53H80N7O9/c1-35(2)30-40(56-50(66)69-51(5,6)7)27-26-39(31-37-20-14-12-15-21-37)48(64)59-29-19-25-43(59)46(62)58-44(36(3)4)47(63)57-42(24-18-28-54-49(65)68-34-38-22-16-13-17-23-38)45(61)55-41-32-52(8,9)60(67)53(10,11)33-41/h12-17,20-23,26-27,35-36,39-44H,18-19,24-25,28-34H2,1-11H3,(H,54,65)(H,55,61)(H,56,66)(H,57,63)(H,58,62)/b27-26+/t39-,40-,42+,43+,44+/m1/s1
Stdinchikey:	VDQKIDYOPUMJGQ-VQPCLXHQSA-N
C:	53
H:	80
N:	7
O:	9

XJB-5-131 is a synthetic antioxidant. In a mouse model of Huntington's disease, it has been shown to reduce oxidative damage to mitochondrial DNA, and to maintain mitochondrial DNA copy number.^[1] XJB-5-131 also strongly protects against ferroptosis, a form of iron-dependent regulated cell death.^[2]

Notes and References

Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, Robbins PD, Niedernhofer LJ, Wipf P, McMurray CT . 6 . Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease . Cell Reports . 2 . 5 . 1137–42 . November 2012 . 23122961 . 3513647 . 10.1016/j.celrep.2012.10.001 .
Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P . A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis . ACS Central Science . 2 . 9 . 653–659 . September 2016 . 27725964 . 5043442 . 10.1021/acscentsci.6b00199 .