The XII Venice Challenge Save Cup was a professional tennis tournament played on clay courts. It was the 1st edition of the men's tournament which was part of the 2014 ATP Challenger Tour. It took place in Mestre, Italy between 2 and 8 June 2014.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Paolo Lorenzi | 88 | 1 | |
 Spain | Daniel Gimeno Traver | 94 | 2 | |
| Italy | Filippo Volandri | 99 | 3 | |
 Tunisia | Malek Jaziri | 116 | 4 | |
 Argentina | Horacio Zeballos | 122 | 5 | |
| Pablo Cuevas | 136 | 6 | ||
| Argentina | Facundo Bagnis | 143 | 7 | |
| Italy | Marco Cecchinato | 156 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Pablo Cuevas | Argentina | Horacio Zeballos | 80 | 1 | ||
| Italy | Daniele Bracciali | Italy | Potito Starace | 204 | 2 | |
| Dominik Meffert | Tim Puetz | 236 | 3 | |||
 Colombia | Nicolás Barrientos | Colombia | Juan Carlos Spir | 251 | 4 |
The following pairs received wildcards into the doubles main draw:
Andrea Basso / Gianluca Mager Daniele Giorgini / Matteo Volante Marco Cecchinato, 6–4, 4–6, 6–2 Horacio Zeballos def. Daniele Bracciali / Potito Starace, 6–4, 6–1