The XIII Venice Challenge Save Cup is a professional tennis tournament played on clay courts. It is the 2nd edition of the men's tournament which was part of the 2015 ATP Challenger Tour. It took place in Mestre, Italy between 1 and 7 June 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Paolo Lorenzi | 86 | 1 | ||
| Facundo Bagnis | 96 | 2 | ||
| Guido Pella | 113 | 3 | ||
| Máximo González | 114 | 4 | ||
| Yoshihito Nishioka | 146 | 5 | ||
| Bjorn Fratangelo | 149 | 6 | ||
| Gastão Elias | 152 | 7 | ||
| Guilherme Clezar | 172 | 8 |
The following players received wildcards into the singles main draw:
Matteo Berrettini Edoardo Eremin Gianluigi Quinzi Matteo ViolaThe following player received entry as alternate:
The following players received entry from the qualifying draw:
| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Argentina | Guido Andreozzi | Argentina | Andrés Molteni | 258 | 1 | |
| Argentina | Facundo Bagnis |  Peru | Sergio Galdós | 294 | 2 | |
| Italy | Flavio Cipolla | Italy | Potito Starace | 329 | 3 | |
| Dino Marcan | Antonio Šančić | 354 | 4 |
The following pairs received wildcards into the doubles main draw:
Sam Barnett / Jesse Witten Matteo Berrettini / Gianluigi Quinzi Edoardo Eremin / Pietro Rondoni Máximo González def. 
Jozef Kovalík, 6–1, 6–3 Flavio Cipolla / Potito Starace def. Facundo Bagnis / Sergio Galdós, 5–7, 7–6(7–3), [10–4]
