CAPOX explained

CAPOX (also called XELOX^[1]) is a chemotherapy regimen consisting of capecitabine (trade name Xeloda) combined with oxaliplatin.^{[2] [3]}

Xelox regime operates in 3-week cycles, usually with 8 cycles in total; Xeloda is taken orally twice daily for two weeks, while oxaliplatin is administered by IV on the first day of the cycle; there is a one-week rest period before the next cycle.

Adverse effects

• Neuropathy
• Diarrhea

Notes and References

1. Cassidy . J. . Tabernero . J. . Twelves . C. . Brunet . R. . Butts . C. . Conroy . T. . Debraud . F. . Figer . A. . Grossmann . J. . Sawada . N. . Schöffski . P. . Sobrero . A. . Van Cutsem . E. . Díaz-Rubio . E. . XELOX (Capecitabine Plus Oxaliplatin): Active First-Line Therapy for Patients with Metastatic Colorectal Cancer . 10.1200/JCO.2004.11.069 . Journal of Clinical Oncology . 22 . 11 . 2084–2091 . 2004 . 15169795. free .
2. http://www.medscape.com/viewarticle/727049 Capecitabine Combined with Oxaliplatin (CapOx) in Clinical Practice: How Significant is Peripheral Neuropathy?
3. Twelves C, Wong A, Nowacki MP . Capecitabine as adjuvant treatment for stage III colon cancer . N. Engl. J. Med. . 352 . 26 . 2696–704 . June 2005 . 15987918 . 10.1056/NEJMoa043116 . etal. free .