XAP044 explained

XAP044 is a drug which acts as a potent and selective antagonist of the metabotropic glutamate receptor 7 (mGluR₇). It inhibits long-term potentiation in the amygdala and inhibits responses associated with stress and anxiety in animal models,^[1] as well as being used to study the role of mGluR₇ in various other processes.^{[2] [3] [4]}

Notes and References

1. Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S, Cryan JF, van der Putten H, Fendt M, Vranesic I, Glatthar R, Flor PJ . 6 . Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior . The Journal of Biological Chemistry . 289 . 16 . 10975–10987 . April 2014 . 24596089 . 10.1074/jbc.M113.542654 . 4036238 . free .
2. Hajasova Z, Canestrelli C, Acher F, Noble F, Marie N . Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist . Neuropharmacology . 131 . 424–430 . March 2018 . 29307544 . 10.1016/j.neuropharm.2018.01.002 . 3391450 .
3. Gryksa K, Mittmann L, Bauer A, Peterlik D, Flor PJ, Uschold-Schmidt N, Bosch OJ . Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice . Genes, Brain and Behavior . 19 . 1 . e12627 . January 2020 . 31793148 . 10.1111/gbb.12627 . 208609219 . free .
4. Estrela KA, Senninger L, Arndt J, Kabas M, Schmid F, Dillmann L, Auer S, Stepfer T, Flor PJ, Uschold-Schmidt N . 6 . Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice . Cells . 11 . 11 . June 2022 . 1817 . 35681512 . 10.3390/cells11111817 . 9180111 . free .