XAGE1D explained

G antigen family D member 2 is a protein that in humans is encoded by the XAGE1D gene.^[1]

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.^[2]

Further reading

• Brinkmann U, Vasmatzis G, Lee B, Pastan I . Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database . Cancer Research . 59 . 7 . 1445–8 . April 1999 . 10197611 .
• Liu XF, Helman LJ, Yeung C, Bera TK, Lee B, Pastan I . XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma . Cancer Research . 60 . 17 . 4752–5 . September 2000 . 10987281 .
• Zendman AJ, van Kraats AA, den Hollander AI, Weidle UH, Ruiter DJ, van Muijen GN . Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis . International Journal of Cancer . 97 . 2 . 195–204 . January 2002 . 11774264 . 10.1002/ijc.1584 . 36598913 .
• Zendman AJ, Van Kraats AA, Weidle UH, Ruiter DJ, Van Muijen GN . The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma . International Journal of Cancer . 99 . 3 . 361–9 . May 2002 . 11992404 . 10.1002/ijc.10371 . 45958151 . free .
• Egland KA, Kumar V, Duray P, Pastan I . Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers . Molecular Cancer Therapeutics . 1 . 7 . 441–50 . May 2002 . 12479262 .
• Lim JH, Kim SP, Gabrielson E, Park YB, Park JW, Kwon TK . Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation . International Journal of Cancer . 116 . 2 . 200–6 . August 2005 . 15800911 . 10.1002/ijc.21007 . 25575235 .
• Nakagawa K, Noguchi Y, Uenaka A, Sato S, Okumura H, Tanaka M, Shimono M, Ali Eldib AM, Ono T, Ohara N, Yoshino T, Yamashita K, Tsunoda T, Aoe M, Shimizu N, Nakayama E . 6 . XAGE-1 expression in non-small cell lung cancer and antibody response in patients . Clinical Cancer Research . 11 . 15 . 5496–503 . August 2005 . 16061866 . 10.1158/1078-0432.CCR-05-0216 . 8514961 .
• Sato S, Noguchi Y, Ohara N, Uenaka A, Shimono M, Nakagawa K, Koizumi F, Ishida T, Yoshino T, Shiratori Y, Nakayama E . 6 . Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors . Cancer Immunity . 7 . 5 . March 2007 . 17335148 . 2935747 .

Notes and References

1. Web site: Entrez Gene: XAGE1 X antigen family, member 1.
2. Web site: Entrez Gene: XAGE1 X antigen family, member 1.