X-linked hypertrichosis explained

Synonym:	X-linked congenital generalized hypertrichosis
Specialty:	Dermatology

X-linked hypertrichosis, also known as X-linked congenital generalized hypertrichosis, is a hereditary disorders characterized by generalized congenital hypertrichosis and thick eyebrows.^[1]

Signs and symptoms

Hypertrichosis is characterized as excessive hair growth anywhere on the body, in either men or women.^[2] X-linked hypertrichosis affects males more than females.^[3]

Causes

X-linked hypertrichosis was first mapped in chromosome Xq24-q27.1 in a Mexican family; however, the underlying genetic facts remain unknown.^[4] X-linked hypertrichosis is inherited in an X-linked dominant pattern of inheritance.^[3]

See also

• Generalized hyperhidrosis
• List of cutaneous conditions

Further reading

• DeStefano . Gina M. . Fantauzzo . Katherine A. . Petukhova . Lynn . Kurban . Mazen . Tadin-Strapps . Marija . Levy . Brynn . Warburton . Dorothy . Cirulli . Elizabeth T. . Han . Yujun . Sun . Xiaoyun . Shen . Yufeng . Shirazi . Maryam . Jobanputra . Vaidehi . Cepeda-Valdes . Rodrigo . Cesar Salas-Alanis . Julio . Christiano . Angela M. . Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis . Proceedings of the National Academy of Sciences . 110 . 19 . 2013-05-07 . 0027-8424 . 23603273 . 3651487 . 10.1073/pnas.1216412110 . 7790–7795 . free . none.
• Figuera . Luis E. . Pandolfo . Massimo . Dunne . Patrick W. . Cantú . Jose M. . Patel . Pragna I. . Mapping of the congenital generalized hypertrichosis locus to chromosome Xq24–q27.1 . Nature Genetics . Springer Science and Business Media LLC . 10 . 2 . 1995 . 1061-4036 . 10.1038/ng0695-202 . 202–207 . 7663516 . none.

Notes and References

1. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 1008 . 978-1-4160-2999-1 .
2. Web site: Saleh . Dahlia . Yarrarapu . Siva Naga S. . Cook . Christopher . Hypertrichosis . StatPearls Publishing . 2023-08-16 . 30521275 . 2024-04-27.
3. Macías-Flores . M. A. . García-Cruz . D. . Rivera . H. . Escobar-Luján . M. . Melendrez-Vega . A. . Rivas-Campos . D. . Rodríguez-Collazo . F. . Moreno-Arellano . I. . Cantu . J. M. . A new form of hypertrichosis inherited as an X-linked dominant trait . Human Genetics . 66 . 1 . 1984 . 0340-6717 . 10.1007/BF00275189 . 66–70.
4. Zhu. Hongwen. Shang. Dandan. Sun. Miao. Choi. Sunju. Liu. Qing. Hao. Jiajie. Figuera. Luis E.. Zhang. Feng. Choy. Kwong Wai. Ao. Yang. Liu. Yang. 2011-06-10. X-Linked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific Palindrome near SOX3. American Journal of Human Genetics. 88. 6. 819–826. 10.1016/j.ajhg.2011.05.004. 0002-9297. 3113246. 21636067.