X-Trp aminopeptidase explained

Xaa-Trp aminopeptidase
Ec Number:3.4.11.16
Cas Number:137010-33-4

Xaa-Trp aminopeptidase (aminopeptidase W, aminopeptidase X-Trp) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction

Release of a variety of N-terminal residues (especially glutamate and leucine) from peptides, provided tryptophan (or at least phenylalanine or tyrosine) is the penultimate residue. Also acts on Glu!Trp, Leu!Trp and a number of other dipeptides

This glycoprotein contains Zn2+.

Notes and References

  1. Gee NS, Kenny AJ . Proteins of the kidney microvillar membrane. The 130 kDa protein in pig kidney, recognized by monoclonal antibody GK5C1, is an ectoenzyme with aminopeptidase activity . The Biochemical Journal . 230 . 3 . 753–64 . September 1985 . 4062876 . 1152680 . 10.1042/bj2300753 .
  2. Gee NS, Kenny AJ . Proteins of the kidney microvillar membrane. Enzymic and molecular properties of aminopeptidase W . The Biochemical Journal . 246 . 1 . 97–102 . August 1987 . 2890346 . 1148244 . 10.1042/bj2460097 .

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