Wrch1 Explained

RhoU (or Wrch1 or Chp2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases.Wrch1 was identified in 2001 as encoded by a non-canonical Wnt induced gene.[1] RhoU/Wrch delineates with RhoV/Chp a Rho subclass related to Rac and Cdc42, which emerged in early multicellular organisms during evolution.[2]

Notes and References

  1. Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ . 2001 . Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1 . Genes Dev . 15 . 14 . 1796–807 . 0890-9369. 10.1101/gad.894301 . 11459829 . 312736.
  2. Boureux A, Vignal E, Faure S, Fort P . 2007 . Evolution of the Rho family of ras-like GTPases in eukaryotes . Mol Biol Evol . 24 . 1 . 203–16 . 0021-9193 . 17035353 . 10.1093/molbev/msl145 . 2665304.

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